Replication study of common variants in CDKAL1 and CDKN2A/2B genes associated with type 2 diabetes in Lebanese Arab population

Replication study of common variants in CDKAL1 and CDKN2A/2B genes associated with type 2 diabetes in Lebanese Arab population

Abstract We investigated the association of CDKAL1 (rs7754840 and rs7756992) and CDKN2A/2B (rs10811661) variants with T2DM. Higher MAF of rs7754840 and rs7756992 were seen in patients, and both were associated with T2DM under additive, dominant, and recessive models. CDKAL1 rs7754840 and rs7756992,...

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Veröffentlicht in:Diabetes research and clinical practice 2012-02, Vol.95 (2), p.e37-e40
Hauptverfasser: Nemr, Rita, Almawi, Ahmad W, Echtay, Akram, Sater, Mai S, Daher, Hoda S, Almawi, Wassim Y
Format: Artikel
Sprache:eng
Schlagworte:
Arabs - genetics
CDKAL1
CDKN2A/2B
Cyclin-Dependent Kinase 5 - genetics
Cyclin-Dependent Kinase Inhibitor p15 - genetics
Cyclin-Dependent Kinase Inhibitor p16 - genetics
Diabetes
Diabetes Mellitus, Type 2 - genetics
Endocrinology & Metabolism
Genetic Predisposition to Disease
Genome-Wide Association Study
Haplotypes
Humans
Lebanon - epidemiology
Polymorphism, Single Nucleotide
Replication studies
Transcription Factors
tRNA Methyltransferases
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Zusammenfassung:Abstract We investigated the association of CDKAL1 (rs7754840 and rs7756992) and CDKN2A/2B (rs10811661) variants with T2DM. Higher MAF of rs7754840 and rs7756992 were seen in patients, and both were associated with T2DM under additive, dominant, and recessive models. CDKAL1 rs7754840 and rs7756992, but not CDKN2A/2B rs10811661, are associated with T2DM in Lebanese.
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2011.11.002