A controlled clinical trial with pirfenidone in the treatment of pathological skin scarring caused by burns in pediatric patients

Pathologic skin scarring reversion remains a big challenge for surgeons, as disfiguring scars have a dramatic influence on patient's quality of life. A controlled clinical trial was conducted to evaluate 8% pirfenidone (PFD) gel administered topically 3 times a day during 6 months to 33 pediatr...

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Veröffentlicht in:Annals of plastic surgery 2012-01, Vol.68 (1), p.22-28
Hauptverfasser: Armendariz-Borunda, Juan, Lyra-Gonzalez, Ivan, Medina-Preciado, David, Gonzalez-García, Ignacio, Martinez-Fong, Daniel, Miranda, Rodolfo Ariel, Magaña-Castro, Rogelio, Peña-Santoyo, Pedro, Garcia-Rocha, Sergio, Bautista, Carlos Alfredo, Godoy, Jesus, Flores-Montana, Jesus, Floresvillar-Mosqueda, Jorge, Armendariz-Vazquez, Oscar, Lucano-Landeros, Martha Silvia, Vazquez-Del Mercado, Monica, Sanchez-Parada, Maria G
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Sprache:eng
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Zusammenfassung:Pathologic skin scarring reversion remains a big challenge for surgeons, as disfiguring scars have a dramatic influence on patient's quality of life. A controlled clinical trial was conducted to evaluate 8% pirfenidone (PFD) gel administered topically 3 times a day during 6 months to 33 pediatric patients with hypertrophic scars caused by burns. A total of 30 patients with hypertrophic scars with identical Vancouver Scar Scale values were treated with pressure therapy and included as controls. Improvements were evaluated by Vancouver Scar Scale and a Visual Analog Scale. Safety parameters were determined by the presence of adverse events and monitoring laboratory and hematology parameters. Patients treated with PFD during 6 months presented a continuous monthly statistically significant scar regression in comparison with the initial Vancouver measurement (P =
ISSN:0148-7043
1536-3708
DOI:10.1097/SAP.0b013e31821b6d08