A controlled clinical trial with pirfenidone in the treatment of pathological skin scarring caused by burns in pediatric patients
Pathologic skin scarring reversion remains a big challenge for surgeons, as disfiguring scars have a dramatic influence on patient's quality of life. A controlled clinical trial was conducted to evaluate 8% pirfenidone (PFD) gel administered topically 3 times a day during 6 months to 33 pediatr...
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Veröffentlicht in: | Annals of plastic surgery 2012-01, Vol.68 (1), p.22-28 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Pathologic skin scarring reversion remains a big challenge for surgeons, as disfiguring scars have a dramatic influence on patient's quality of life.
A controlled clinical trial was conducted to evaluate 8% pirfenidone (PFD) gel administered topically 3 times a day during 6 months to 33 pediatric patients with hypertrophic scars caused by burns. A total of 30 patients with hypertrophic scars with identical Vancouver Scar Scale values were treated with pressure therapy and included as controls. Improvements were evaluated by Vancouver Scar Scale and a Visual Analog Scale. Safety parameters were determined by the presence of adverse events and monitoring laboratory and hematology parameters.
Patients treated with PFD during 6 months presented a continuous monthly statistically significant scar regression in comparison with the initial Vancouver measurement (P = |
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ISSN: | 0148-7043 1536-3708 |
DOI: | 10.1097/SAP.0b013e31821b6d08 |