Preparation and characterisation of solid state forms of paracetamol-O-glucuronide

Preparation and characterisation of solid state forms of paracetamol-O-glucuronide

The synthesis and crystallisation of the pharmaceutically important metabolite, paracetamol-O-glucuronide, is described. Hydrated and anhydrous forms of the target molecule have been characterised by PXRD, DSC and TGA. In addition, a methanol solvate has been analysed, including single crystal analy...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Carbohydrate research 2012-02, Vol.349, p.108-112
Hauptverfasser: Hayes, John A., Eccles, Kevin S., Lawrence, Simon E., Moynihan, Humphrey A.
Format: Artikel
Sprache:eng
Schlagworte:
Acetaminophen - chemical synthesis
Acetaminophen - chemistry
Carbohydrate Conformation
crystallization
Glucuronides - chemical synthesis
Glucuronides - chemistry
Hydrates
metabolites
methanol
Models, Molecular
Paracetamol-O-glucuronide
Solvates
X-ray diffraction
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The synthesis and crystallisation of the pharmaceutically important metabolite, paracetamol-O-glucuronide, is described. Hydrated and anhydrous forms of the target molecule have been characterised by PXRD, DSC and TGA. In addition, a methanol solvate has been analysed, including single crystal analysis, which represents the first structure solution for this system.
ISSN:0008-6215
1873-426X
DOI:10.1016/j.carres.2011.12.018