Discovery of Novel Stem Cell Mobilizers That Target the CXCR4 Receptor

Going mobile: Based on screening hit 1, a novel class of polyamine compounds, as represented by compound 8, were identified as potent and selective CXCR4 antagonists. CXCR4‐targeted molecules, as demonstrated by the marketed AMD3100 and 8, are able to mobilize stem cells from bone marrow effectively...

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Veröffentlicht in:	ChemMedChem 2012-02, Vol.7 (2), p.209-212
Hauptverfasser:	Wu, Chien-Huang, Chang, Chun-Ping, Song, Jen-Shin, Jan, Jiing-Jyh, Chou, Ming-Chen, Wu, Szu-Huei, Yeh, Kai-Chia, Wong, Ying-Chieh, Hsieh, Chieh-Jui, Chen, Chiung-Tong, Kao, Tzu-Ting, Wu, Su-Ying, Yeh, Ching-Fang, Tseng, Chen-Tso, Chao, Yu-Sheng, Shia, Kak-Shan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals chemokines CXCR4 Drug Evaluation, Preclinical GPCRs Hematopoietic Stem Cell Mobilization Hematopoietic Stem Cells - cytology Heterocyclic Compounds - chemistry Heterocyclic Compounds - pharmacology Injections, Subcutaneous Male Mice Mice, Inbred C57BL PBSC transplantation Polyamines - chemistry Pyrimidines - chemistry Quinazolines - chemical synthesis Quinazolines - chemistry Quinazolines - pharmacology Receptors, CXCR4 - antagonists & inhibitors Receptors, CXCR4 - metabolism Regenerative Medicine SDF-1 structure-activity relationships
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Beschreibung
Zusammenfassung:	Going mobile: Based on screening hit 1, a novel class of polyamine compounds, as represented by compound 8, were identified as potent and selective CXCR4 antagonists. CXCR4‐targeted molecules, as demonstrated by the marketed AMD3100 and 8, are able to mobilize stem cells from bone marrow effectively and are expected to have broad utility in cell therapy and regenerative medicine.
ISSN:	1860-7179 1860-7187
DOI:	10.1002/cmdc.201100525