Vaginal progesterone in women with an asymptomatic sonographic short cervix in the midtrimester decreases preterm delivery and neonatal morbidity: a systematic review and metaanalysis of individual patient data

Objective To determine whether the use of vaginal progesterone in asymptomatic women with a sonographic short cervix (≤25 mm) in the midtrimester reduces the risk of preterm birth and improves neonatal morbidity and mortality. Study Design Individual patient data metaanalysis of randomized controlle...

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Veröffentlicht in:	American journal of obstetrics and gynecology 2012-02, Vol.206 (2), p.124.e1-124.e19
Hauptverfasser:	Romero, Roberto, MD, Nicolaides, Kypros, MD, Conde-Agudelo, Agustin, MD, MPH, Tabor, Ann, MD, O'Brien, John M., MD, Cetingoz, Elcin, MD, Da Fonseca, Eduardo, MD, Creasy, George W., MD, Klein, Katharina, MD, Rode, Line, MD, Soma-Pillay, Priya, MD, Fusey, Shalini, MD, Cam, Cetin, MD, Alfirevic, Zarko, MD, Hassan, Sonia S., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	17α-hydroxyprogesterone caproate Administration, Intravaginal admission to neonatal intensive care unit Biological and medical sciences birthweight <1500 g Diseases of mother, fetus and pregnancy Female Gynecology. Andrology. Obstetrics Humans mechanical ventilation Medical sciences Obstetrics and Gynecology Pregnancy Pregnancy Trimester, Second Pregnancy. Fetus. Placenta Premature Birth - prevention & control prematurity preterm birth Progesterone - administration & dosage Progesterone - therapeutic use progestin Progestins - therapeutic use respiratory distress syndrome Risk transvaginal ultrasound Treatment Outcome uterine cervix
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Beschreibung
Zusammenfassung:	Objective To determine whether the use of vaginal progesterone in asymptomatic women with a sonographic short cervix (≤25 mm) in the midtrimester reduces the risk of preterm birth and improves neonatal morbidity and mortality. Study Design Individual patient data metaanalysis of randomized controlled trials. Results Five trials of high quality were included with a total of 775 women and 827 infants. Treatment with vaginal progesterone was associated with a significant reduction in the rate of preterm birth
ISSN:	0002-9378 1097-6868
DOI:	10.1016/j.ajog.2011.12.003