IL-1 receptor–associated kinase 3 gene ( IRAK3 ) variants associate with asthma in a replication study in the Spanish population
Risk allele Minor allele frequency Association tests Spanish Sardinian Italian Japanese Individual studiesOR (95% CI)[low *]; P value Meta-analysisOR (95% CI)[low *]; P value Control subjects (n = 1271) Cases[dagger] (n= 139) Control subjects (n = 460) Cases (n = 139) Control subjects (n = 278) Case...
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| Veröffentlicht in: | Journal of allergy and clinical immunology 2012-02, Vol.129 (2), p.573-575.e10 |
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| creator | Pino-Yanes, María, MSc Sánchez-Machín, Inmaculada, MD Cumplido, José, MD Figueroa, Javier, MD Torres-Galván, María José, PhD González, Ruperto, MD Corrales, Almudena, CLT Acosta-Fernández, Orlando, MD García-Robaina, José Carlos, MD Carrillo, Teresa, MD Sánchez-Palacios, Anselmo, MD Villar, Jesús, MD, PhD Hernández, Mariano, PhD Flores, Carlos, PhD |
| description | Risk allele Minor allele frequency Association tests Spanish Sardinian Italian Japanese Individual studiesOR (95% CI)[low *]; P value Meta-analysisOR (95% CI)[low *]; P value Control subjects (n = 1271) Cases[dagger] (n= 139) Control subjects (n = 460) Cases (n = 139) Control subjects (n = 278) Cases (n = 67) Control subjects (n = 639) Cases (n = 391) Spanish[double dagger] Sardinian Italian Japanese§ Europeans All samples§ rs1732887 A 0.26 0.21     0.10 0.09 1.28 (0.96-1.72); .082   1.06 (0.78-1.43); .725  1.18 (0.95-1.46); .1420 rs2701653 T 0.09 0.13     0.41 0.43 1.49 (1.03-2.14); .034   1.05 (0.87-1.25); .620  1.11 (0.95-1.31); .1791 rs1732886 A 0.26 0.21 0.21 0.16     1.32 (0.98-1.75); .061 1.40 (0.98-2.00); .106   1.36 (1.08-1.72); .0105  rs1882200 T 0.33 0.38 0.34 0.46     1.25 (0.97-1.61); .105 1.65 (1.26-2.17); .001   1.42 (1.18-1.71); .0002  rs11465955 T 0.33 0.39 0.35 0.46 0.34 0.43   1.28 (0.99-1.64); .058 1.56 (1.18-2.04); .001 1.48 (1.01-2.18); .029  1.42 (1.2-1.68); .0001  rs2293657 T 0.29 0.35 0.34 0.46   0.12 0.15 1.32 (1.01-1.71); .010 1.65 (1.26-2.17); .001  1.07 (0.82-1.39); .180 1.47 (1.22-1.77); .0001 1.31 (1.13-1.53); .0004 rs1152888 A 0.08 0.11     0.40 0.40 1.46 (0.98-2.17); .07   0.96 (0.81-1.15); .839  1.03 (0.87-1.21); .3719 rs1821777 T 0.34 0.39 0.36 0.46     1.22 (0.94-1.57); .088 1.54 (1.17-2.02); .001   1.36 (1.13-1.63); .0013  rs1624395 A 0.39 0.48 0.42 0.51 0.40 0.53   1.40 (1.09-1.79); .007 1.46 (1.11-1.91); .002 1.68 (1.15-2.46); .004  1.47 (1.25-1.74); 5.7 x 10-6  rs1370128 T 0.42 0.49 0.43 0.54 0.41 0.55   1.46 (1.14-1.87); .001 1.53 (1.16-2.00); .001 1.76 (1.21-2.58); .002  1.54 (1.31-1.82); 2.9 x 10-7  rs10716217 delA 0.42 0.49     0.54 0.55 1.50 (1.17-1.92); .001   1.04 (0.87-1.24); .685  1.17 (1.02-1.36); .0295 Table E6 Meta-analysis of IRAK3 SNPs in unrelated case-control samples  Coverage (%) SNP array HapMap CEU Resequencing Affymetrix 500K 63 29 Affymetrix Genome-Wide Human SNP Array 6.0 93 71 Illumina HumanHap300[dagger] 77 19 Illumina HumanHap550[double dagger] 83 35 Illumina HumanHap650Y 83 42 Illumina 1M-Duo 97 65 Table E7 Coverage of SNPs from the IRAK3 gene with MAFs of 5% or greater on commercial arrays used in asthma GWASs in samples of European ancestry[low *] CEU, Ancestry from northern and western Europe. |
| doi_str_mv | 10.1016/j.jaci.2011.10.001 |
| format | Article |
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Sánchez-Machín, Inmaculada, MD ; Cumplido, José, MD ; Figueroa, Javier, MD ; Torres-Galván, María José, PhD ; González, Ruperto, MD ; Corrales, Almudena, CLT ; Acosta-Fernández, Orlando, MD ; García-Robaina, José Carlos, MD ; Carrillo, Teresa, MD ; Sánchez-Palacios, Anselmo, MD ; Villar, Jesús, MD, PhD ; Hernández, Mariano, PhD ; Flores, Carlos, PhD</creator><creatorcontrib>Pino-Yanes, María, MSc ; Sánchez-Machín, Inmaculada, MD ; Cumplido, José, MD ; Figueroa, Javier, MD ; Torres-Galván, María José, PhD ; González, Ruperto, MD ; Corrales, Almudena, CLT ; Acosta-Fernández, Orlando, MD ; García-Robaina, José Carlos, MD ; Carrillo, Teresa, MD ; Sánchez-Palacios, Anselmo, MD ; Villar, Jesús, MD, PhD ; Hernández, Mariano, PhD ; Flores, Carlos, PhD</creatorcontrib><description>Risk allele Minor allele frequency Association tests Spanish Sardinian Italian Japanese Individual studiesOR (95% CI)[low *]; P value Meta-analysisOR (95% CI)[low *]; P value Control subjects (n = 1271) Cases[dagger] (n= 139) Control subjects (n = 460) Cases (n = 139) Control subjects (n = 278) Cases (n = 67) Control subjects (n = 639) Cases (n = 391) Spanish[double dagger] Sardinian Italian Japanese§ Europeans All samples§ rs1732887 A 0.26 0.21     0.10 0.09 1.28 (0.96-1.72); .082   1.06 (0.78-1.43); .725  1.18 (0.95-1.46); .1420 rs2701653 T 0.09 0.13     0.41 0.43 1.49 (1.03-2.14); .034   1.05 (0.87-1.25); .620  1.11 (0.95-1.31); .1791 rs1732886 A 0.26 0.21 0.21 0.16     1.32 (0.98-1.75); .061 1.40 (0.98-2.00); .106   1.36 (1.08-1.72); .0105  rs1882200 T 0.33 0.38 0.34 0.46     1.25 (0.97-1.61); .105 1.65 (1.26-2.17); .001   1.42 (1.18-1.71); .0002  rs11465955 T 0.33 0.39 0.35 0.46 0.34 0.43   1.28 (0.99-1.64); .058 1.56 (1.18-2.04); .001 1.48 (1.01-2.18); .029  1.42 (1.2-1.68); .0001  rs2293657 T 0.29 0.35 0.34 0.46   0.12 0.15 1.32 (1.01-1.71); .010 1.65 (1.26-2.17); .001  1.07 (0.82-1.39); .180 1.47 (1.22-1.77); .0001 1.31 (1.13-1.53); .0004 rs1152888 A 0.08 0.11     0.40 0.40 1.46 (0.98-2.17); .07   0.96 (0.81-1.15); .839  1.03 (0.87-1.21); .3719 rs1821777 T 0.34 0.39 0.36 0.46     1.22 (0.94-1.57); .088 1.54 (1.17-2.02); .001   1.36 (1.13-1.63); .0013  rs1624395 A 0.39 0.48 0.42 0.51 0.40 0.53   1.40 (1.09-1.79); .007 1.46 (1.11-1.91); .002 1.68 (1.15-2.46); .004  1.47 (1.25-1.74); 5.7 x 10-6  rs1370128 T 0.42 0.49 0.43 0.54 0.41 0.55   1.46 (1.14-1.87); .001 1.53 (1.16-2.00); .001 1.76 (1.21-2.58); .002  1.54 (1.31-1.82); 2.9 x 10-7  rs10716217 delA 0.42 0.49     0.54 0.55 1.50 (1.17-1.92); .001   1.04 (0.87-1.24); .685  1.17 (1.02-1.36); .0295 Table E6 Meta-analysis of IRAK3 SNPs in unrelated case-control samples  Coverage (%) SNP array HapMap CEU Resequencing Affymetrix 500K 63 29 Affymetrix Genome-Wide Human SNP Array 6.0 93 71 Illumina HumanHap300[dagger] 77 19 Illumina HumanHap550[double dagger] 83 35 Illumina HumanHap650Y 83 42 Illumina 1M-Duo 97 65 Table E7 Coverage of SNPs from the IRAK3 gene with MAFs of 5% or greater on commercial arrays used in asthma GWASs in samples of European ancestry[low *] CEU, Ancestry from northern and western Europe.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2011.10.001</identifier><identifier>PMID: 22070913</identifier><identifier>CODEN: JACIBY</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adolescent ; Adult ; Age ; Allergy and Immunology ; Asthma - genetics ; Asthma - immunology ; Biological and medical sciences ; Case-Control Studies ; Chronic obstructive pulmonary disease, asthma ; Europe - epidemiology ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Genealogy ; Genes ; Genetic Predisposition to Disease ; Genomes ; Haplotypes ; Humans ; Immunopathology ; Interleukin-1 Receptor-Associated Kinases - genetics ; Male ; Medical sciences ; Methods ; Middle Aged ; Pneumology ; Polymorphism, Single Nucleotide ; Population ; Principal components analysis ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Spain ; Young Adult</subject><ispartof>Journal of allergy and clinical immunology, 2012-02, Vol.129 (2), p.573-575.e10</ispartof><rights>American Academy of Allergy, Asthma & Immunology</rights><rights>2011 American Academy of Allergy, Asthma & Immunology</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Elsevier Limited Feb 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-1466703a0687a97d0778f1b22aa640db0ff85f83f82258bebd2e91a2aea0e9b63</citedby><cites>FETCH-LOGICAL-c468t-1466703a0687a97d0778f1b22aa640db0ff85f83f82258bebd2e91a2aea0e9b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jaci.2011.10.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25595663$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22070913$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pino-Yanes, María, MSc</creatorcontrib><creatorcontrib>Sánchez-Machín, Inmaculada, MD</creatorcontrib><creatorcontrib>Cumplido, José, MD</creatorcontrib><creatorcontrib>Figueroa, Javier, MD</creatorcontrib><creatorcontrib>Torres-Galván, María José, PhD</creatorcontrib><creatorcontrib>González, Ruperto, MD</creatorcontrib><creatorcontrib>Corrales, Almudena, CLT</creatorcontrib><creatorcontrib>Acosta-Fernández, Orlando, MD</creatorcontrib><creatorcontrib>García-Robaina, José Carlos, MD</creatorcontrib><creatorcontrib>Carrillo, Teresa, MD</creatorcontrib><creatorcontrib>Sánchez-Palacios, Anselmo, MD</creatorcontrib><creatorcontrib>Villar, Jesús, MD, PhD</creatorcontrib><creatorcontrib>Hernández, Mariano, PhD</creatorcontrib><creatorcontrib>Flores, Carlos, PhD</creatorcontrib><title>IL-1 receptor–associated kinase 3 gene ( IRAK3 ) variants associate with asthma in a replication study in the Spanish population</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>Risk allele Minor allele frequency Association tests Spanish Sardinian Italian Japanese Individual studiesOR (95% CI)[low *]; P value Meta-analysisOR (95% CI)[low *]; P value Control subjects (n = 1271) Cases[dagger] (n= 139) Control subjects (n = 460) Cases (n = 139) Control subjects (n = 278) Cases (n = 67) Control subjects (n = 639) Cases (n = 391) Spanish[double dagger] Sardinian Italian Japanese§ Europeans All samples§ rs1732887 A 0.26 0.21     0.10 0.09 1.28 (0.96-1.72); .082   1.06 (0.78-1.43); .725  1.18 (0.95-1.46); .1420 rs2701653 T 0.09 0.13     0.41 0.43 1.49 (1.03-2.14); .034   1.05 (0.87-1.25); .620  1.11 (0.95-1.31); .1791 rs1732886 A 0.26 0.21 0.21 0.16     1.32 (0.98-1.75); .061 1.40 (0.98-2.00); .106   1.36 (1.08-1.72); .0105  rs1882200 T 0.33 0.38 0.34 0.46     1.25 (0.97-1.61); .105 1.65 (1.26-2.17); .001   1.42 (1.18-1.71); .0002  rs11465955 T 0.33 0.39 0.35 0.46 0.34 0.43   1.28 (0.99-1.64); .058 1.56 (1.18-2.04); .001 1.48 (1.01-2.18); .029  1.42 (1.2-1.68); .0001  rs2293657 T 0.29 0.35 0.34 0.46   0.12 0.15 1.32 (1.01-1.71); .010 1.65 (1.26-2.17); .001  1.07 (0.82-1.39); .180 1.47 (1.22-1.77); .0001 1.31 (1.13-1.53); .0004 rs1152888 A 0.08 0.11     0.40 0.40 1.46 (0.98-2.17); .07   0.96 (0.81-1.15); .839  1.03 (0.87-1.21); .3719 rs1821777 T 0.34 0.39 0.36 0.46     1.22 (0.94-1.57); .088 1.54 (1.17-2.02); .001   1.36 (1.13-1.63); .0013  rs1624395 A 0.39 0.48 0.42 0.51 0.40 0.53   1.40 (1.09-1.79); .007 1.46 (1.11-1.91); .002 1.68 (1.15-2.46); .004  1.47 (1.25-1.74); 5.7 x 10-6  rs1370128 T 0.42 0.49 0.43 0.54 0.41 0.55   1.46 (1.14-1.87); .001 1.53 (1.16-2.00); .001 1.76 (1.21-2.58); .002  1.54 (1.31-1.82); 2.9 x 10-7  rs10716217 delA 0.42 0.49     0.54 0.55 1.50 (1.17-1.92); .001   1.04 (0.87-1.24); .685  1.17 (1.02-1.36); .0295 Table E6 Meta-analysis of IRAK3 SNPs in unrelated case-control samples  Coverage (%) SNP array HapMap CEU Resequencing Affymetrix 500K 63 29 Affymetrix Genome-Wide Human SNP Array 6.0 93 71 Illumina HumanHap300[dagger] 77 19 Illumina HumanHap550[double dagger] 83 35 Illumina HumanHap650Y 83 42 Illumina 1M-Duo 97 65 Table E7 Coverage of SNPs from the IRAK3 gene with MAFs of 5% or greater on commercial arrays used in asthma GWASs in samples of European ancestry[low *] CEU, Ancestry from northern and western Europe.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Allergy and Immunology</subject><subject>Asthma - genetics</subject><subject>Asthma - immunology</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Europe - epidemiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Genealogy</subject><subject>Genes</subject><subject>Genetic Predisposition to Disease</subject><subject>Genomes</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>Immunopathology</subject><subject>Interleukin-1 Receptor-Associated Kinases - genetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methods</subject><subject>Middle Aged</subject><subject>Pneumology</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population</subject><subject>Principal components analysis</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Spain</subject><subject>Young Adult</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9ks-KFDEQxhtR3HX1BTxIQEQ99Jiku9MJiLAs_hkcEFw9h-p0tZPZnnRvkl6Zm_gKvqFPYtoZd2EPnkJV_eqjUl9l2WNGF4wy8Wqz2ICxC04ZS4kFpexOdsyoqnMheXU3O6ZUsVzUpTrKHoSwoSkupLqfHXFO61QrjrOfy1XOiEeDYxz87x-_IITBWIjYkgvrICApyDd0SF6Q5efTjwV5Sa7AW3AxkGuWfLdxncK43gKxjkBSHHtrINrBkRCndjen4xrJ-QjOhjUZh3Hq_9YfZvc66AM-Orwn2dd3b7-cfchXn94vz05XuSmFjDkrhahpAVTIGlTd0rqWHWs4BxAlbRvadbLqZNFJzivZYNNyVAw4IFBUjShOsud73dEPlxOGqLc2GOx7cDhMQSsmVcFpqRL59Ba5GSbv0nCaibJMC60qlii-p4wfQvDY6dHbLfidZlTPBumNng3Ss0FzLhmUmp4cpKdmi-11yz9HEvDsAEAw0HcenLHhhqsqVQkxc6_3HKaVXVn0OhiLzmBrk5tRt4P9_xxvbrWb3rrkWH-BOww3_9WBa6rP51OaL4klwUqUsvgDpXnC5g</recordid><startdate>20120201</startdate><enddate>20120201</enddate><creator>Pino-Yanes, María, MSc</creator><creator>Sánchez-Machín, Inmaculada, MD</creator><creator>Cumplido, José, MD</creator><creator>Figueroa, Javier, MD</creator><creator>Torres-Galván, María José, PhD</creator><creator>González, Ruperto, MD</creator><creator>Corrales, Almudena, CLT</creator><creator>Acosta-Fernández, Orlando, MD</creator><creator>García-Robaina, José Carlos, MD</creator><creator>Carrillo, Teresa, MD</creator><creator>Sánchez-Palacios, Anselmo, MD</creator><creator>Villar, Jesús, MD, PhD</creator><creator>Hernández, Mariano, PhD</creator><creator>Flores, Carlos, PhD</creator><general>Mosby, Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20120201</creationdate><title>IL-1 receptor–associated kinase 3 gene ( IRAK3 ) variants associate with asthma in a replication study in the Spanish population</title><author>Pino-Yanes, María, MSc ; Sánchez-Machín, Inmaculada, MD ; Cumplido, José, MD ; Figueroa, Javier, MD ; Torres-Galván, María José, PhD ; González, Ruperto, MD ; Corrales, Almudena, CLT ; Acosta-Fernández, Orlando, MD ; García-Robaina, José Carlos, MD ; Carrillo, Teresa, MD ; Sánchez-Palacios, Anselmo, MD ; Villar, Jesús, MD, PhD ; Hernández, Mariano, PhD ; Flores, Carlos, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-1466703a0687a97d0778f1b22aa640db0ff85f83f82258bebd2e91a2aea0e9b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Allergy and Immunology</topic><topic>Asthma - genetics</topic><topic>Asthma - immunology</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Europe - epidemiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Genealogy</topic><topic>Genes</topic><topic>Genetic Predisposition to Disease</topic><topic>Genomes</topic><topic>Haplotypes</topic><topic>Humans</topic><topic>Immunopathology</topic><topic>Interleukin-1 Receptor-Associated Kinases - genetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methods</topic><topic>Middle Aged</topic><topic>Pneumology</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Population</topic><topic>Principal components analysis</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Spain</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pino-Yanes, María, MSc</creatorcontrib><creatorcontrib>Sánchez-Machín, Inmaculada, MD</creatorcontrib><creatorcontrib>Cumplido, José, MD</creatorcontrib><creatorcontrib>Figueroa, Javier, MD</creatorcontrib><creatorcontrib>Torres-Galván, María José, PhD</creatorcontrib><creatorcontrib>González, Ruperto, MD</creatorcontrib><creatorcontrib>Corrales, Almudena, CLT</creatorcontrib><creatorcontrib>Acosta-Fernández, Orlando, MD</creatorcontrib><creatorcontrib>García-Robaina, José Carlos, MD</creatorcontrib><creatorcontrib>Carrillo, Teresa, MD</creatorcontrib><creatorcontrib>Sánchez-Palacios, Anselmo, MD</creatorcontrib><creatorcontrib>Villar, Jesús, MD, PhD</creatorcontrib><creatorcontrib>Hernández, Mariano, PhD</creatorcontrib><creatorcontrib>Flores, Carlos, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pino-Yanes, María, MSc</au><au>Sánchez-Machín, Inmaculada, MD</au><au>Cumplido, José, MD</au><au>Figueroa, Javier, MD</au><au>Torres-Galván, María José, PhD</au><au>González, Ruperto, MD</au><au>Corrales, Almudena, CLT</au><au>Acosta-Fernández, Orlando, MD</au><au>García-Robaina, José Carlos, MD</au><au>Carrillo, Teresa, MD</au><au>Sánchez-Palacios, Anselmo, MD</au><au>Villar, Jesús, MD, PhD</au><au>Hernández, Mariano, PhD</au><au>Flores, Carlos, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IL-1 receptor–associated kinase 3 gene ( IRAK3 ) variants associate with asthma in a replication study in the Spanish population</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>2012-02-01</date><risdate>2012</risdate><volume>129</volume><issue>2</issue><spage>573</spage><epage>575.e10</epage><pages>573-575.e10</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><coden>JACIBY</coden><abstract>Risk allele Minor allele frequency Association tests Spanish Sardinian Italian Japanese Individual studiesOR (95% CI)[low *]; P value Meta-analysisOR (95% CI)[low *]; P value Control subjects (n = 1271) Cases[dagger] (n= 139) Control subjects (n = 460) Cases (n = 139) Control subjects (n = 278) Cases (n = 67) Control subjects (n = 639) Cases (n = 391) Spanish[double dagger] Sardinian Italian Japanese§ Europeans All samples§ rs1732887 A 0.26 0.21     0.10 0.09 1.28 (0.96-1.72); .082   1.06 (0.78-1.43); .725  1.18 (0.95-1.46); .1420 rs2701653 T 0.09 0.13     0.41 0.43 1.49 (1.03-2.14); .034   1.05 (0.87-1.25); .620  1.11 (0.95-1.31); .1791 rs1732886 A 0.26 0.21 0.21 0.16     1.32 (0.98-1.75); .061 1.40 (0.98-2.00); .106   1.36 (1.08-1.72); .0105  rs1882200 T 0.33 0.38 0.34 0.46     1.25 (0.97-1.61); .105 1.65 (1.26-2.17); .001   1.42 (1.18-1.71); .0002  rs11465955 T 0.33 0.39 0.35 0.46 0.34 0.43   1.28 (0.99-1.64); .058 1.56 (1.18-2.04); .001 1.48 (1.01-2.18); .029  1.42 (1.2-1.68); .0001  rs2293657 T 0.29 0.35 0.34 0.46   0.12 0.15 1.32 (1.01-1.71); .010 1.65 (1.26-2.17); .001  1.07 (0.82-1.39); .180 1.47 (1.22-1.77); .0001 1.31 (1.13-1.53); .0004 rs1152888 A 0.08 0.11     0.40 0.40 1.46 (0.98-2.17); .07   0.96 (0.81-1.15); .839  1.03 (0.87-1.21); .3719 rs1821777 T 0.34 0.39 0.36 0.46     1.22 (0.94-1.57); .088 1.54 (1.17-2.02); .001   1.36 (1.13-1.63); .0013  rs1624395 A 0.39 0.48 0.42 0.51 0.40 0.53   1.40 (1.09-1.79); .007 1.46 (1.11-1.91); .002 1.68 (1.15-2.46); .004  1.47 (1.25-1.74); 5.7 x 10-6  rs1370128 T 0.42 0.49 0.43 0.54 0.41 0.55   1.46 (1.14-1.87); .001 1.53 (1.16-2.00); .001 1.76 (1.21-2.58); .002  1.54 (1.31-1.82); 2.9 x 10-7  rs10716217 delA 0.42 0.49     0.54 0.55 1.50 (1.17-1.92); .001   1.04 (0.87-1.24); .685  1.17 (1.02-1.36); .0295 Table E6 Meta-analysis of IRAK3 SNPs in unrelated case-control samples  Coverage (%) SNP array HapMap CEU Resequencing Affymetrix 500K 63 29 Affymetrix Genome-Wide Human SNP Array 6.0 93 71 Illumina HumanHap300[dagger] 77 19 Illumina HumanHap550[double dagger] 83 35 Illumina HumanHap650Y 83 42 Illumina 1M-Duo 97 65 Table E7 Coverage of SNPs from the IRAK3 gene with MAFs of 5% or greater on commercial arrays used in asthma GWASs in samples of European ancestry[low *] CEU, Ancestry from northern and western Europe.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>22070913</pmid><doi>10.1016/j.jaci.2011.10.001</doi><tpages>3</tpages></addata></record> |
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| subjects | Adolescent Adult Age Allergy and Immunology Asthma - genetics Asthma - immunology Biological and medical sciences Case-Control Studies Chronic obstructive pulmonary disease, asthma Europe - epidemiology Female Fundamental and applied biological sciences. Psychology Fundamental immunology Genealogy Genes Genetic Predisposition to Disease Genomes Haplotypes Humans Immunopathology Interleukin-1 Receptor-Associated Kinases - genetics Male Medical sciences Methods Middle Aged Pneumology Polymorphism, Single Nucleotide Population Principal components analysis Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Spain Young Adult |
| title | IL-1 receptor–associated kinase 3 gene ( IRAK3 ) variants associate with asthma in a replication study in the Spanish population |
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