IL-1 receptor–associated kinase 3 gene ( IRAK3 ) variants associate with asthma in a replication study in the Spanish population

Risk allele Minor allele frequency Association tests Spanish Sardinian Italian Japanese Individual studiesOR (95% CI)[low *]; P value Meta-analysisOR (95% CI)[low *]; P value Control subjects (n = 1271) Cases[dagger] (n= 139) Control subjects (n = 460) Cases (n = 139) Control subjects (n = 278) Cases (n = 67) Control subjects (n = 639) Cases (n = 391) Spanish[double dagger] Sardinian Italian Japanese§ Europeans All samples§ rs1732887 A 0.26 0.21     0.10 0.09 1.28 (0.96-1.72); .082   1.06 (0.78-1.43); .725  1.18 (0.95-1.46); .1420 rs2701653 T 0.09 0.13     0.41 0.43 1.49 (1.03-2.14); .034   1.05 (0.87-1.25); .620  1.11 (0.95-1.31); .1791 rs1732886 A 0.26 0.21 0.21 0.16     1.32 (0.98-1.75); .061 1.40 (0.98-2.00); .106   1.36 (1.08-1.72); .0105  rs1882200 T 0.33 0.38 0.34 0.46     1.25 (0.97-1.61); .105 1.65 (1.26-2.17); .001   1.42 (1.18-1.71); .0002  rs11465955 T 0.33 0.39 0.35 0.46 0.34 0.43   1.28 (0.99-1.64); .058 1.56 (1.18-2.04); .001 1.48 (1.01-2.18); .029  1.42 (1.2-1.68); .0001  rs2293657 T 0.29 0.35 0.34 0.46   0.12 0.15 1.32 (1.01-1.71); .010 1.65 (1.26-2.17); .001  1.07 (0.82-1.39); .180 1.47 (1.22-1.77); .0001 1.31 (1.13-1.53); .0004 rs1152888 A 0.08 0.11     0.40 0.40 1.46 (0.98-2.17); .07   0.96 (0.81-1.15); .839  1.03 (0.87-1.21); .3719 rs1821777 T 0.34 0.39 0.36 0.46     1.22 (0.94-1.57); .088 1.54 (1.17-2.02); .001   1.36 (1.13-1.63); .0013  rs1624395 A 0.39 0.48 0.42 0.51 0.40 0.53   1.40 (1.09-1.79); .007 1.46 (1.11-1.91); .002 1.68 (1.15-2.46); .004  1.47 (1.25-1.74); 5.7 x 10-6  rs1370128 T 0.42 0.49 0.43 0.54 0.41 0.55   1.46 (1.14-1.87); .001 1.53 (1.16-2.00); .001 1.76 (1.21-2.58); .002  1.54 (1.31-1.82); 2.9 x 10-7  rs10716217 delA 0.42 0.49     0.54 0.55 1.50 (1.17-1.92); .001   1.04 (0.87-1.24); .685  1.17 (1.02-1.36); .0295 Table E6 Meta-analysis of IRAK3 SNPs in unrelated case-control samples  Coverage (%) SNP array HapMap CEU Resequencing Affymetrix 500K 63 29 Affymetrix Genome-Wide Human SNP Array 6.0 93 71 Illumina HumanHap300[dagger] 77 19 Illumina HumanHap550[double dagger] 83 35 Illumina HumanHap650Y 83 42 Illumina 1M-Duo 97 65 Table E7 Coverage of SNPs from the IRAK3 gene with MAFs of 5% or greater on commercial arrays used in asthma GWASs in samples of European ancestry[low *] CEU, Ancestry from northern and western Europe.