A Synthetic C34 Trimer of HIV-1 gp41 Shows Significant Increase in Inhibition Potency

Supramolecular interference: A synthetic peptide mimetic of the trimeric form of gp41 showed significantly increased inhibitory activity against the HIV‐1 fusion mechanism. This study demonstrates a useful strategy for the design of effective inhibitors against viral infections that proceed by membr...

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Veröffentlicht in:	ChemMedChem 2012-02, Vol.7 (2), p.205-208
Hauptverfasser:	Nomura, Wataru, Hashimoto, Chie, Ohya, Aki, Miyauchi, Kosuke, Urano, Emiko, Tanaka, Tomohiro, Narumi, Tetsuo, Nakahara, Toru, Komano, Jun A., Yamamoto, Naoki, Tamamura, Hirokazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Anti-HIV Agents - pharmacology antiviral agents C34 trimers Cell Line fusion inhibitors gp41 HIV Envelope Protein gp41 - antagonists & inhibitors HIV Envelope Protein gp41 - chemical synthesis HIV Envelope Protein gp41 - chemistry HIV Envelope Protein gp41 - metabolism HIV Envelope Protein gp41 - pharmacology HIV Fusion Inhibitors - chemical synthesis HIV Fusion Inhibitors - chemistry HIV Fusion Inhibitors - pharmacology HIV-1 HIV-1 - drug effects HIV-1 - metabolism Human immunodeficiency virus 1 Humans Peptide Fragments - chemical synthesis Peptide Fragments - chemistry Peptide Fragments - pharmacology Protein Multimerization
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Zusammenfassung:	Supramolecular interference: A synthetic peptide mimetic of the trimeric form of gp41 showed significantly increased inhibitory activity against the HIV‐1 fusion mechanism. This study demonstrates a useful strategy for the design of effective inhibitors against viral infections that proceed by membrane fusion with host cells.
ISSN:	1860-7179 1860-7187
DOI:	10.1002/cmdc.201100542