The cationic lipid, diC14 amidine, extends the adjuvant properties of aluminum salts through a TLR-4- and caspase-1-independent mechanism

Highlights ► We design a novel adjuvant system based on aluminum salts. ► Cationic lipid diC14 amidine improves innate detection of alum. ► Mixed preparation outperforms sequential addition of both immunomodulators. ► Processing of alum-adsorbed antigen benefits from coupling with diC14 amidine. ► d...

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Veröffentlicht in:	Vaccine 2012-01, Vol.30 (2), p.414-424
Hauptverfasser:	Wilmar, Arnaud, Lonez, Caroline, Vermeersch, Marjorie, Andrianne, Mathieu, Pérez-Morga, David, Ruysschaert, Jean-Marie, Vandenbranden, Michel, Leo, Oberdan, Temmerman, Stéphane T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant Adjuvants, Immunologic - administration & dosage agonists Allergy and Immunology Alum Alum Compounds - administration & dosage Aluminum Amidines - administration & dosage Animals Antigen processing antigen-presenting cells antigens Caspase 1 - immunology caspase-1 Cationic agent Cell-mediated immunity Cells, Cultured coculture Cytotoxicity Experiments Female humans Humoral immunity immune response Immune system Immunity, Cellular Immunity, Humoral immunoglobulins Innate immunity interleukin-1beta Interleukin-1beta - secretion Lipids macrophages Macrophages - immunology Male Medical research Mice Mice, Inbred C57BL Models, Animal Ovalbumin - immunology pathogens salts Standard deviation T-lymphocytes Toll-Like Receptor 4 - immunology vaccination Vaccine Vaccines Vaccines, Subunit - administration & dosage Vaccines, Subunit - immunology
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Zusammenfassung:	Highlights ► We design a novel adjuvant system based on aluminum salts. ► Cationic lipid diC14 amidine improves innate detection of alum. ► Mixed preparation outperforms sequential addition of both immunomodulators. ► Processing of alum-adsorbed antigen benefits from coupling with diC14 amidine. ► diC14 amidine enhances antigen-specific humoral and cellular immunity induced by alum.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2011.10.071