Cbx Proteins Help ESCs Walk the Line between Self-Renewal and Differentiation

Cbx Proteins Help ESCs Walk the Line between Self-Renewal and Differentiation

The Polycomb repressive complexes (PRC) regulate self-renewal and differentiation in embryonic stem cells (ESCs). In this issue of Cell Stem Cell, Morey et al. (2012) and O'Loghlen et al. (2012) report that dynamic interchange of PRC subunits modulates the balance between self-renewal and linea...

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Veröffentlicht in:Cell stem cell 2012-01, Vol.10 (1), p.4-6
Hauptverfasser: Camahort, Raymond, Cowan, Chad A.
Format: Artikel
Sprache:eng
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Zusammenfassung:The Polycomb repressive complexes (PRC) regulate self-renewal and differentiation in embryonic stem cells (ESCs). In this issue of Cell Stem Cell, Morey et al. (2012) and O'Loghlen et al. (2012) report that dynamic interchange of PRC subunits modulates the balance between self-renewal and lineage commitment in ESCs.
ISSN:1934-5909
1875-9777
DOI:10.1016/j.stem.2011.12.011