Synthesis and biological evaluation of molecular probes based on the 9-methylstreptimidone derivative DTCM-glutarimide

Molecular probes based on 3-[(dodecylthiocarbonyl)methyl]glutarimide (DTCM-glutarimide) were synthesized and assessed for inhibitory activity against LPS-induced NO production. Among the probes examined, several derivatives exhibited potential for use in determining the target proteins of DTCM-gluta...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2012-01, Vol.22 (1), p.164-167
Hauptverfasser:	Ota, Eisuke, Takeiri, Masatoshi, Tachibana, Miyuki, Ishikawa, Yuichi, Umezawa, Kazuo, Nishiyama, Shigeru
Format:	Artikel
Sprache:	eng
Schlagworte:	9-Methylstreptimidone Animals Biological and medical sciences Biotinylation Cell Line Chemistry, Pharmaceutical - methods Drug Design Humans Jurkat Cells Lipopolysaccharides - chemistry Lipopolysaccharides - pharmacology Medical sciences Mice Models, Chemical Molecular probe Molecular Probes - chemistry NF-kappa B - metabolism NF-κB nitric oxide Nitric Oxide - chemistry Pharmacology. Drug treatments Piperidones - chemical synthesis Piperidones - pharmacology proteins Streptomyces sp synthesis Time Factors
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Zusammenfassung:	Molecular probes based on 3-[(dodecylthiocarbonyl)methyl]glutarimide (DTCM-glutarimide) were synthesized and assessed for inhibitory activity against LPS-induced NO production. Among the probes examined, several derivatives exhibited potential for use in determining the target proteins of DTCM-glutarimide.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2011.11.045