A new route to indoles via in situ desilylation–Sonogashira strategy: identification of novel small molecules as potential anti-tuberculosis agents

A new route to indoles via in situ desilylation–Sonogashira strategy: identification of novel small molecules as potential anti-tuberculosis agents

A new Pd/C-mediated tandem reaction has been developed for the one pot synthesis of indoles containing an o-(RSO2NH)C6H4 group at the C-2 position. The methodology provided novel indoles as inhibitors of Mycobacterium tuberculosis H37Rv chorismate mutase in vitro representing the first example of ch...

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Veröffentlicht in:MedChemComm 2011-10, Vol.2 (10), p.1006-1010
Hauptverfasser: Nakhi, Ali, Prasad, Bagineni, Reddy, Uppender, Rao, Raja Mohan, Sandra, Sandhya, Kapavarapu, Ravikumar, Rambabu, D., Rama Krishna, G., Reddy, C. Malla, Ravada, Kishore, Misra, Parimal, Iqbal, Javed, Pal, Manojit
Format: Artikel
Sprache:eng
Schlagworte:
Chorismate mutase
Indole
Mycobacterium tuberculosis
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Zusammenfassung:A new Pd/C-mediated tandem reaction has been developed for the one pot synthesis of indoles containing an o-(RSO2NH)C6H4 group at the C-2 position. The methodology provided novel indoles as inhibitors of Mycobacterium tuberculosis H37Rv chorismate mutase in vitro representing the first example of chorismate mutase inhibition by a heteroarene based small molecule.
ISSN:2040-2503
2040-2511
DOI:10.1039/c1md00148e