Efficacy of a capsule conjugate vaccine against inhalational anthrax in rabbits and monkeys

Highlights ► An anthrax vaccine was produced by conjugating the capsule to a protein carrier. ► The anthrax capsule conjugate vaccine induced opsono-adherence antibodies. ► The capsule conjugate vaccine protected monkeys against inhalational anthrax. ► The capsule is the first non-toxin antigen show...

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Veröffentlicht in:	Vaccine 2012-01, Vol.30 (5), p.846-852
Hauptverfasser:	Chabot, Donald J, Joyce, Joseph, Caulfield, Michael, Cook, James, Hepler, Robert, Wang, Su, Vietri, Nicholas J, Ruthel, Gordon, Shoop, Wesley, Pitt, Louise, Leffel, Elizabeth, Ribot, Wilson, Friedlander, Arthur M
Format:	Artikel
Sprache:	eng
Schlagworte:	aerosols Allergy and Immunology Animals Anthrax Anthrax - immunology Anthrax - prevention & control Anthrax Vaccines - administration & dosage Anthrax Vaccines - immunology Antibodies, Bacterial - blood antigens Bacillus anthracis Bacterial Capsules - chemistry Bacterial Capsules - immunology Bacterial Outer Membrane Proteins - chemistry Bacterial Outer Membrane Proteins - isolation & purification Bacteriology bioterrorism Capsule Conjugate Disease Models, Animal Enzyme-Linked Immunosorbent Assay Female humans Lymphocytes Macaca mulatta macrophages Macrophages - immunology Male mice monkeys Mortality Neisseria meningitidis Neisseria meningitidis - chemistry Opsonin Proteins - blood outer membrane proteins Phagocytosis Proteins Rabbits serotypes spores Streptococcus infections Studies Survival Analysis Toxins Vaccine Vaccines Vaccines, Conjugate - administration & dosage Vaccines, Conjugate - immunology virulence
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Beschreibung
Zusammenfassung:	Highlights ► An anthrax vaccine was produced by conjugating the capsule to a protein carrier. ► The anthrax capsule conjugate vaccine induced opsono-adherence antibodies. ► The capsule conjugate vaccine protected monkeys against inhalational anthrax. ► The capsule is the first non-toxin antigen shown to protect monkeys against anthrax.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2011.12.010