Early antiretroviral therapy in HIV-1-infected infants, 1996-2008: treatment response and duration of first-line regimens

To investigate virological and immunological response to antiretroviral therapy (ART), and predictors of switching and interrupting treatment among infants starting ART across Europe. Cohort study. Nine cohorts from 13 European countries contributed data on HIV-infected infants born 1996-2008 and st...

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Veröffentlicht in:	AIDS (London) 2011-11, Vol.25 (18), p.2279-2287
1. Verfasser:	Judd, Ali
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired Immunodeficiency Syndrome - drug therapy Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences CD4 Lymphocyte Count Cohort Studies Drug Therapy, Combination - methods Europe Female HIV Infections - drug therapy HIV Infections - immunology HIV Infections - virology HIV Protease Inhibitors - administration & dosage Human immunodeficiency virus Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infant Infant, Newborn Infectious diseases Male Medical sciences Pharmacology. Drug treatments Reverse Transcriptase Inhibitors - administration & dosage Treatment Outcome Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load
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Beschreibung
Zusammenfassung:	To investigate virological and immunological response to antiretroviral therapy (ART), and predictors of switching and interrupting treatment among infants starting ART across Europe. Cohort study. Nine cohorts from 13 European countries contributed data on HIV-infected infants born 1996-2008 and starting ART before age 12 months. Logistic and linear regression, and competing risks methods were used to assess predictors of virological (viral load
ISSN:	0269-9370 1473-5571
DOI:	10.1097/QAD.0b013e32834d614c