Ratiometric fluorescence imaging for distinguishing chloride concentration between normal and ischemic ventricular myocytes

Ratiometric fluorescence imaging for distinguishing chloride concentration between normal and ischemic ventricular myocytes

We devised a new ratiometric fluorescent probe for the detection of chloride ions. This synthesized probe was applied to the ventricular myocytes to successfully realize dynamic imaging of Cl(-) concentration fluctuations during the myocardial ischemia course.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2012-01, Vol.48 (15), p.2077-2079
Hauptverfasser: Li, Ping, Xie, Ting, Fan, Nannan, Li, Kexiang, Tang, Bo
Format: Artikel
Sprache:eng
Schlagworte:
Chloride ions
Chlorides
Chlorides - analysis
Dynamics
Fluctuation
Fluoresceins - chemistry
Fluorescence
Fluorescent Dyes - chemistry
Heart Ventricles - cytology
Heart Ventricles - pathology
Humans
Imaging
Ischemia
Microscopy, Confocal
Myocardial Ischemia - metabolism
Myocardial Ischemia - pathology
Myocytes, Cardiac - cytology
Myocytes, Cardiac - pathology
Quinolines - chemistry
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Beschreibung
Zusammenfassung:We devised a new ratiometric fluorescent probe for the detection of chloride ions. This synthesized probe was applied to the ventricular myocytes to successfully realize dynamic imaging of Cl(-) concentration fluctuations during the myocardial ischemia course.
ISSN:1359-7345
1364-548X
DOI:10.1039/c1cc15258k