TLR1 polymorphisms in Europeans and spontaneous pregnancy loss
Toll-like receptors (TLRs) are critical components of the pathogen recognition by the host innate immune system. Recently it has been shown that TLR1 is under evolutionary pressure in Europeans. This involves the positive selection of the nonsynonymous TLR1 1805G variant in Europeans, although this...
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Veröffentlicht in: | Gene 2012-02, Vol.494 (1), p.109-111 |
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Sprache: | eng |
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Zusammenfassung: | Toll-like receptors (TLRs) are critical components of the pathogen recognition by the host innate immune system. Recently it has been shown that TLR1 is under evolutionary pressure in Europeans. This involves the positive selection of the nonsynonymous TLR1 1805G variant in Europeans, although this is associated with poor TLR1 response and unfavorable prognosis in various infections. In terms of natural selection, differential fertility is another mechanism, independent of infection susceptibility, that may explain the polymorphism pattern observed for TLR1. To test this hypothesis, we assessed the correlation of two TLR1 SNPs (T1805G and G239C) with spontaneous pregnancy loss in a case–control study that included 132 spontaneous pregnancy loss patients and 142 control volunteers. Similar allele frequencies of T1805G were observed between cases and controls, but GG genotype tended to be associated with pregnancy loss (OR 1.91; 95%CI 1.03, 3.53). No differences were observed for the TLR1 G239C SNP. Our findings showed slight differences in the distribution of T1805G variants in women with pregnancy loss, but these were not indicative of a protective effect of the TLR1 1805G allele for this fertility disorder. Although our hypothesis was not proven, potential effects of TLR1 polymorphisms on pregnancy outcome have been suggested, and future studies in larger cohorts are warranted.
► The TLR1 T1805G polymorphism is a target of positive selection in Europeans. ► We hypothesize that this SNP confers selective advantage for fertility in Europeans. ► We study the association of two TLR1 SNPs with spontaneous pregnancy loss (SPL). ► The TLR1 T1805G SNP is associated with a higher risk for SPL. ► The high frequency of this SNP is not likely due to an advantage for fertility. |
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ISSN: | 0378-1119 1879-0038 |
DOI: | 10.1016/j.gene.2011.12.008 |