Isolation and Total Synthesis of Icumazoles and Noricumazoles-Antifungal Antibiotics and Cation-Channel Blockers from Sorangium cellulosum

Joint efforts: The antifungal icumazole A, the potassium‐ion‐channel inhibitor noricumazole A, and their glycosylated derivatives are new, structurally related secondary metabolites isolated from Sorangium cellulosum. Their structures have been fully assigned by a joint strategy that relied on spect...

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Veröffentlicht in:	Angewandte Chemie International Edition 2012-01, Vol.51 (5), p.1256-1260
Hauptverfasser:	Barbier, Jenny, Jansen, Rolf, Irschik, Herbert, Benson, Stefan, Gerth, Klaus, Böhlendorf, Bettina, Höfle, Gerhard, Reichenbach, Hans, Wegner, Jens, Zeilinger, Carsten, Kirschning, Andreas, Müller, Rolf
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - isolation & purification Azoles - chemical synthesis Azoles - isolation & purification Cations Ion Channels - antagonists & inhibitors Ion Channels - chemistry ion-channel inhibitors myxobacteria Myxococcales - chemistry natural products structure elucidation total synthesis
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Beschreibung
Zusammenfassung:	Joint efforts: The antifungal icumazole A, the potassium‐ion‐channel inhibitor noricumazole A, and their glycosylated derivatives are new, structurally related secondary metabolites isolated from Sorangium cellulosum. Their structures have been fully assigned by a joint strategy that relied on spectroscopy, derivatization, fragmentation, and finally the first total synthesis of noricumazole A.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201106435