Neuroprotector Effect of Comenic Acid against Cytotoxic Action of Glutamate in Vitro in Cultured Neurons of Lead-Poisoned Rat Pups

We demonstrated an increase in glutamate neurocytotoxicity in cultured cerebellar cells from rat pups subjected to lead poisoning during the prenatal development or early lactation period. The toxic effect of glutamate was weaker, if lead was applied in combination with antioxidant comenic acid. The...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2011-02, Vol.150 (4), p.436-439
Hauptverfasser:	Kravtsov, A. A, Shurygin, A. Ya, Skorokhod, N. S, Khaspekov, L. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Animals, Newborn Antioxidants Biomedical and Life Sciences Biomedicine Brain Brain - drug effects Brain - metabolism Brain - pathology Carboxylic Acids - pharmacology Cell Biology cell culture Cells, Cultured Cerebellum comenic acid Cytotoxicity Data processing Development Female Glutamate Glutamates - toxicity Glutamic acid Internal Medicine Laboratory Medicine Lactation Lead lead poisoning Lead Poisoning, Nervous System - drug therapy Neurons Neurons - drug effects Neurons - metabolism Neurons - pathology Neuroprotective Agents - pharmacology oxidative stress Pathology Poisoning Pregnancy Pyrones - pharmacology Rats Rats, Wistar
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Zusammenfassung:	We demonstrated an increase in glutamate neurocytotoxicity in cultured cerebellar cells from rat pups subjected to lead poisoning during the prenatal development or early lactation period. The toxic effect of glutamate was weaker, if lead was applied in combination with antioxidant comenic acid. These data are discussed in view of practical use of comenic acid for the therapy of the brain tissues subjected to lead poisoning.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-011-1162-x