Validity and usefulness of B-type natriuretic peptide (BNP) for early detection of left ventricular dysfunction in high-risk patients in primary care

The aim of this study was to determine the accuracy of BNP test for early diagnosis of left ventricular dysfunction in patients at high-risk for heart failure. Cross-sectional descriptive study. 7 Primary Care Centres in Madrid (Spain). A consecutive sample of 204 consecutive asymptomatic patients w...

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Veröffentlicht in:Atención primaria 2012-01, Vol.44 (1), p.13-19
Hauptverfasser: Lobos Bejarano, José M, Horrillo García, Cristina, González-González, Ana I, Castellanos Rodríguez, Angel, Díaz Sánchez, Santiago, Castellanos Maroto, Javier, Rodriguez-Barrientos, Ricardo, García-Fernández, Miguel A
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Sprache:spa
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Zusammenfassung:The aim of this study was to determine the accuracy of BNP test for early diagnosis of left ventricular dysfunction in patients at high-risk for heart failure. Cross-sectional descriptive study. 7 Primary Care Centres in Madrid (Spain). A consecutive sample of 204 consecutive asymptomatic patients with high risk for heart failure (Stages A-B, AHA/ACC Classification). BNP plasma levels were measured in the clinical setting using Triage BNP Test(®) (Biosite(®)) and an echocardiography was performed in the following 3 days in a single hospital unit as a reference standard. Plasma BNP levels were compared depending on the presence/absence of left ventricular dysfunction (LVD), type and severity degree. Sensitivity, specificity, positive and negative predictive values, and Área under the receiver operating characteristic curve (ROC) for BNP assay were calculated. BNP values were significantly higher (P
ISSN:1578-1275
DOI:10.1016/j.aprim.2010.12.009