Polycomb Regulates NF-κB Signaling in Cancer through miRNA

Polycomb Regulates NF-κB Signaling in Cancer through miRNA

The mechanisms leading to the constitutive activation of NF-κB in cancers and the pathways upstream and downstream of this activation are not fully understood. In this issue of Cancer Cell, Yamagishi et al. demonstrate that Polycomb-mediated silencing of miR-31 is implicated in the aberrant activati...

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Veröffentlicht in:Cancer cell 2012-01, Vol.21 (1), p.5-7
Hauptverfasser: Uribesalgo, Iris, Ballaré, Cecilia, Di Croce, Luciano
Format: Artikel
Sprache:eng
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Zusammenfassung:The mechanisms leading to the constitutive activation of NF-κB in cancers and the pathways upstream and downstream of this activation are not fully understood. In this issue of Cancer Cell, Yamagishi et al. demonstrate that Polycomb-mediated silencing of miR-31 is implicated in the aberrant activation of NF-κB signaling in tumors.
ISSN:1535-6108
1878-3686
DOI:10.1016/j.ccr.2011.12.019