A Naphthalimide-Based Glyoxal Hydrazone for Selective Fluorescence Turn-On Sensing of Cys and Hcy
A fluorescent turn-on probe for Cys/Hcy based on inhibiting the CN isomerization quenching process by an intramolecular hydrogen bond was reported. The probe exhibited higher selectivity toward Cys/Hcy over other amino acids as well as thiol-containing compounds.
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| Veröffentlicht in: | Organic letters 2012-01, Vol.14 (2), p.520-523 |
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| container_end_page | 523 |
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| container_issue | 2 |
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| container_title | Organic letters |
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| creator | Wang, Pi Liu, Jing Lv, Xin Liu, Yunlong Zhao, Yun Guo, Wei |
| description | A fluorescent turn-on probe for Cys/Hcy based on inhibiting the CN isomerization quenching process by an intramolecular hydrogen bond was reported. The probe exhibited higher selectivity toward Cys/Hcy over other amino acids as well as thiol-containing compounds. |
| doi_str_mv | 10.1021/ol203123t |
| format | Article |
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The probe exhibited higher selectivity toward Cys/Hcy over other amino acids as well as thiol-containing compounds.</description><identifier>ISSN: 1523-7060</identifier><identifier>EISSN: 1523-7052</identifier><identifier>DOI: 10.1021/ol203123t</identifier><identifier>PMID: 22220759</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Cysteine - chemistry ; Fluorescent Dyes - analysis ; Fluorescent Dyes - chemistry ; Glyoxal - chemistry ; Homocysteine - chemistry ; Hydrazones - analysis ; Hydrazones - chemistry ; Isomerism ; Molecular Structure ; Naphthalimides - chemistry ; Tetrahymena - chemistry</subject><ispartof>Organic letters, 2012-01, Vol.14 (2), p.520-523</ispartof><rights>Copyright © 2012 American Chemical Society</rights><rights>2012 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a380t-97058e49d370cefe935d743811f6f4856e2db4acc6c1c0839a8b8bace838eb893</citedby><cites>FETCH-LOGICAL-a380t-97058e49d370cefe935d743811f6f4856e2db4acc6c1c0839a8b8bace838eb893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/ol203123t$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/ol203123t$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22220759$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Pi</creatorcontrib><creatorcontrib>Liu, Jing</creatorcontrib><creatorcontrib>Lv, Xin</creatorcontrib><creatorcontrib>Liu, Yunlong</creatorcontrib><creatorcontrib>Zhao, Yun</creatorcontrib><creatorcontrib>Guo, Wei</creatorcontrib><title>A Naphthalimide-Based Glyoxal Hydrazone for Selective Fluorescence Turn-On Sensing of Cys and Hcy</title><title>Organic letters</title><addtitle>Org. Lett</addtitle><description>A fluorescent turn-on probe for Cys/Hcy based on inhibiting the CN isomerization quenching process by an intramolecular hydrogen bond was reported. The probe exhibited higher selectivity toward Cys/Hcy over other amino acids as well as thiol-containing compounds.</description><subject>Cysteine - chemistry</subject><subject>Fluorescent Dyes - analysis</subject><subject>Fluorescent Dyes - chemistry</subject><subject>Glyoxal - chemistry</subject><subject>Homocysteine - chemistry</subject><subject>Hydrazones - analysis</subject><subject>Hydrazones - chemistry</subject><subject>Isomerism</subject><subject>Molecular Structure</subject><subject>Naphthalimides - chemistry</subject><subject>Tetrahymena - chemistry</subject><issn>1523-7060</issn><issn>1523-7052</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkMtOwzAQRS0EouWx4AeQNwixCNhxHvayVLRFquiCso4ce0JTuXGxE0T4eoxaumI2M5o5urpzEbqi5J6SmD5YExNGY9YeoSFNYxblJI2PD3NGBujM-zUhNGzEKRrEoUieiiGSI_wit6t2JU29qTVEj9KDxlPT2y9p8KzXTn7bBnBlHX4FA6qtPwFPTGcdeAWNArzsXBMtmnBufN28Y1vhce-xbDSeqf4CnVTSeLjc93P0NnlajmfRfDF9Ho_mkWSctJEInjkkQrOcKKhAsFTnCeOUVlmV8DSDWJeJVCpTVBHOhOQlL6UCzjiUXLBzdLvT3Tr70YFvi00dDBojG7CdLwTNaUZomgTybkcqZ713UBVbV2-k6wtKit9Ai0Oggb3eq3blBvSB_EswADc7QCpfrG2IIjz5j9APvEZ8Qg</recordid><startdate>20120120</startdate><enddate>20120120</enddate><creator>Wang, Pi</creator><creator>Liu, Jing</creator><creator>Lv, Xin</creator><creator>Liu, Yunlong</creator><creator>Zhao, Yun</creator><creator>Guo, Wei</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120120</creationdate><title>A Naphthalimide-Based Glyoxal Hydrazone for Selective Fluorescence Turn-On Sensing of Cys and Hcy</title><author>Wang, Pi ; Liu, Jing ; Lv, Xin ; Liu, Yunlong ; Zhao, Yun ; Guo, Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a380t-97058e49d370cefe935d743811f6f4856e2db4acc6c1c0839a8b8bace838eb893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Cysteine - chemistry</topic><topic>Fluorescent Dyes - analysis</topic><topic>Fluorescent Dyes - chemistry</topic><topic>Glyoxal - chemistry</topic><topic>Homocysteine - chemistry</topic><topic>Hydrazones - analysis</topic><topic>Hydrazones - chemistry</topic><topic>Isomerism</topic><topic>Molecular Structure</topic><topic>Naphthalimides - chemistry</topic><topic>Tetrahymena - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Pi</creatorcontrib><creatorcontrib>Liu, Jing</creatorcontrib><creatorcontrib>Lv, Xin</creatorcontrib><creatorcontrib>Liu, Yunlong</creatorcontrib><creatorcontrib>Zhao, Yun</creatorcontrib><creatorcontrib>Guo, Wei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Organic letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Pi</au><au>Liu, Jing</au><au>Lv, Xin</au><au>Liu, Yunlong</au><au>Zhao, Yun</au><au>Guo, Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Naphthalimide-Based Glyoxal Hydrazone for Selective Fluorescence Turn-On Sensing of Cys and Hcy</atitle><jtitle>Organic letters</jtitle><addtitle>Org. 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| ispartof | Organic letters, 2012-01, Vol.14 (2), p.520-523 |
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| language | eng |
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| source | ACS Publications; MEDLINE |
| subjects | Cysteine - chemistry Fluorescent Dyes - analysis Fluorescent Dyes - chemistry Glyoxal - chemistry Homocysteine - chemistry Hydrazones - analysis Hydrazones - chemistry Isomerism Molecular Structure Naphthalimides - chemistry Tetrahymena - chemistry |
| title | A Naphthalimide-Based Glyoxal Hydrazone for Selective Fluorescence Turn-On Sensing of Cys and Hcy |
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