A Naphthalimide-Based Glyoxal Hydrazone for Selective Fluorescence Turn-On Sensing of Cys and Hcy

A Naphthalimide-Based Glyoxal Hydrazone for Selective Fluorescence Turn-On Sensing of Cys and Hcy

A fluorescent turn-on probe for Cys/Hcy based on inhibiting the CN isomerization quenching process by an intramolecular hydrogen bond was reported. The probe exhibited higher selectivity toward Cys/Hcy over other amino acids as well as thiol-containing compounds.

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Veröffentlicht in:Organic letters 2012-01, Vol.14 (2), p.520-523
Hauptverfasser: Wang, Pi, Liu, Jing, Lv, Xin, Liu, Yunlong, Zhao, Yun, Guo, Wei
Format: Artikel
Sprache:eng
Schlagworte:
Cysteine - chemistry
Fluorescent Dyes - analysis
Fluorescent Dyes - chemistry
Glyoxal - chemistry
Homocysteine - chemistry
Hydrazones - analysis
Hydrazones - chemistry
Isomerism
Molecular Structure
Naphthalimides - chemistry
Tetrahymena - chemistry
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Zusammenfassung:A fluorescent turn-on probe for Cys/Hcy based on inhibiting the CN isomerization quenching process by an intramolecular hydrogen bond was reported. The probe exhibited higher selectivity toward Cys/Hcy over other amino acids as well as thiol-containing compounds.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol203123t