FRET-mediated pH-responsive dual fluorescent nanoparticles prepared via click chemistry

FRET-mediated pH-responsive dual fluorescent nanoparticles prepared via click chemistry

Herein, we report an easy preparation of azide-coated polystyrene-based nanoparticles (15 nm in diameter) and their surface functionalization via CuAAC with fluorophores in water. Resultant dual fluorescent nanoparticles coated with dansyl and pH-sensitive fluorescein moieties as the donor/acceptor...

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Veröffentlicht in:Nanoscale 2012-02, Vol.4 (3), p.727-732
Hauptverfasser: Ouadahi, Karima, Sbargoud, Kamal, Allard, Emmanuel, Larpent, Chantal
Format: Artikel
Sprache:eng
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Zusammenfassung:Herein, we report an easy preparation of azide-coated polystyrene-based nanoparticles (15 nm in diameter) and their surface functionalization via CuAAC with fluorophores in water. Resultant dual fluorescent nanoparticles coated with dansyl and pH-sensitive fluorescein moieties as the donor/acceptor FRET pair show a ratiometric response to pH upon excitation at a single wavelength.
ISSN:2040-3364
2040-3372
DOI:10.1039/c2nr11413e