Salinomycin - A New Cancer Drug Candidate

Very recently, it has been shown that it is possible to selectively kill breast cancer stem cells using the ionophore antibiotic, salinomycin. Its ability to kill cancer stem cells and apoptosis‐resistant cancer cells may define salinomycin as a novel anticancer drug. Very recently it has been shown...

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Veröffentlicht in:	Chemical biology & drug design 2012-03, Vol.79 (3), p.235-238
1. Verfasser:	Huczynski, Adam
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis - drug effects Cell Line, Tumor Cyclin-Dependent Kinase Inhibitor p21 - metabolism DNA Damage drug design drug discovery Humans natural product Neoplasms Neoplastic Stem Cells - drug effects Pyrans - pharmacology therapeutic target
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Beschreibung
Zusammenfassung:	Very recently, it has been shown that it is possible to selectively kill breast cancer stem cells using the ionophore antibiotic, salinomycin. Its ability to kill cancer stem cells and apoptosis‐resistant cancer cells may define salinomycin as a novel anticancer drug. Very recently it has been shown that it is possible to selectively kill breast cancer stem cells using the ionophore antibiotic, salinomycin. Its ability to kill cancer stem cells and apoptosis‐resistant cancer cells may define salinomycin as a novel anticancer drug. Will salinomycin be new cancer killer?
ISSN:	1747-0277 1747-0285
DOI:	10.1111/j.1747-0285.2011.01287.x