LRRK2 and human disease: a complicated question or a question of complexes?

Leucine-rich repeat kinase 2 (LRRK2) is linked to various diseases, including Parkinson's disease, cancer, and leprosy. Data from LRRK2 knockout mice has highlighted a possible role for LRRK2 in regulating signaling pathways that are linked to the pathogenesis of Crohn's disease. Here, we...

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Veröffentlicht in:	Science signaling 2012-01, Vol.5 (207), p.pe2-pe2
Hauptverfasser:	Lewis, Patrick A, Manzoni, Claudia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Crohn Disease - metabolism Disease Models, Animal Gene Expression Regulation Humans Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Mice Mice, Knockout Models, Biological Models, Genetic Neurons - metabolism Parkinson Disease - metabolism Protein Serine-Threonine Kinases - metabolism Protein Serine-Threonine Kinases - physiology Protein Structure, Tertiary Signal Transduction
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Zusammenfassung:	Leucine-rich repeat kinase 2 (LRRK2) is linked to various diseases, including Parkinson's disease, cancer, and leprosy. Data from LRRK2 knockout mice has highlighted a possible role for LRRK2 in regulating signaling pathways that are linked to the pathogenesis of Crohn's disease. Here, we examine how LRRK2's role as a signaling hub in the cell could lead to diverse pathologies.
ISSN:	1945-0877 1937-9145
DOI:	10.1126/scisignal.2002680