Low grade malignant peripheral nerve sheath tumor with mesenchymal differentiation: a case report

Malignant peripheral nerve sheath tumor (MPNST) is an uncommon neoplasm. Rarely, MPNST may display focal mesenchymal differentiation and this is more frequently encountered in high than low grade lesions. Here we present an example of a low grade MPNST with osteoid, cartilaginous and probably smooth...

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Veröffentlicht in:	Polish journal of pathology 2011-12, Vol.62 (4), p.278-281
Hauptverfasser:	Janczar, Karolina, Tybor, Krzysztof, Józefowicz, Mateusz, Papierz, Wielisław
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Adult Biomarkers, Tumor - metabolism Diagnosis, Differential Humans Male Medical prognosis Morphology Mucin-1 - metabolism Musculoskeletal system Neoplasia Neoplasm Recurrence, Local Nerve Sheath Neoplasms - diagnosis Nerve Sheath Neoplasms - metabolism Nerve Sheath Neoplasms - surgery Neurofibroma - diagnosis Protein expression Proteins S100 Proteins - metabolism Sarcoma Skull Base Neoplasms - diagnosis Skull Base Neoplasms - metabolism Skull Base Neoplasms - surgery Smooth muscle Surgery Tumors
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Zusammenfassung:	Malignant peripheral nerve sheath tumor (MPNST) is an uncommon neoplasm. Rarely, MPNST may display focal mesenchymal differentiation and this is more frequently encountered in high than low grade lesions. Here we present an example of a low grade MPNST with osteoid, cartilaginous and probably smooth muscle components occurring in the subtemporal fossa of a 26-year-old male patient with no associated neurofibromatosis type 1. The tumor exhibited diffuse S-100 protein expression, whereas immunostainings for epithelial membrane antigen and smooth muscle actin were positive in a portion of neoplastic cells.
ISSN:	1233-9687 2084-9869