Improvement of gene delivery of PDMAEMA by incorporating a hyperbranched polymer core

A novel strategy to improve the transfection efficiency as well as lower the cytotoxicity for PDMAEMA polycationic vectors has been developed. The cytotoxicity decreases and the transfection efficiency increases significantly through the incorporation of a hydrophobic hyperbranched PEHO core into PD...

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Veröffentlicht in:	Journal of controlled release 2011-11, Vol.152, p.e187-e188
Hauptverfasser:	Cheng, Haixing, Deng, Hui, Zhou, Linzhu, Su, Yue, Yu, Songrui, Zhu, Xinyuan, Zhou, Yongfeng, Yan, Deyue
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Survival - drug effects Cercopithecus aethiops COS Cells Cytotoxicity Dendrimers DNA - chemistry DNA - metabolism Dose-Response Relationship, Drug Gene transfection genes Genes, Reporter Heterocyclic Compounds - chemistry Heterocyclic Compounds - toxicity Hydrophobic and Hydrophilic Interactions hydrophobicity Hyperbranched Luciferases - genetics Luciferases - metabolism Methacrylates - chemistry Methacrylates - toxicity Molecular Structure Molecular Weight Nylons - chemistry Nylons - toxicity PDMAEMA polymers transfection Transfection - methods
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Beschreibung
Zusammenfassung:	A novel strategy to improve the transfection efficiency as well as lower the cytotoxicity for PDMAEMA polycationic vectors has been developed. The cytotoxicity decreases and the transfection efficiency increases significantly through the incorporation of a hydrophobic hyperbranched PEHO core into PDMAEMA. The effectiveness of the hyperbranched architecture for the gene transfection was further proved by comparing the PEHO-star-PDMAEMAs vector with a linear, molecular weight-analogous PEHO core as the control.
ISSN:	0168-3659 1873-4995
DOI:	10.1016/j.jconrel.2011.08.080