Significance of T helper 17 immunity in transplantation
The aim of this review is to provide an overview of significance of T helper 17 (Th17) immunity in acute, chronic and antibody-mediated allograft rejection. The role of Th17 immunity in development of de-novo autoimmunity following transplantation is outlined. It will also consider the impact of Th1...
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| Veröffentlicht in: | Current opinion in organ transplantation 2012-02, Vol.17 (1), p.8-14 |
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| creator | Abadja, Farida Sarraj, Bara Ansari, Mohammed J |
| description | The aim of this review is to provide an overview of significance of T helper 17 (Th17) immunity in acute, chronic and antibody-mediated allograft rejection. The role of Th17 immunity in development of de-novo autoimmunity following transplantation is outlined. It will also consider the impact of Th17 immunity on transplantation tolerance. Potential therapies to target Th17 immunity are discussed.
Interleukin17 (IL-17) is produced by a wide variety of immune and non-immune cells in response to injury. IL-17 production by tubular epithelial cells in response to complement activation in acute antibody-mediated rejection may perpetuate immune injury. Th17-dependent de-novo autoimmunity contributes to chronic allograft rejection. Targeting IL-17 not only inhibits Th17 immunity but also attenuates Th1 immunity by affecting the initial recruitment of immune cells to sites of inflammation and modulates innate and adaptive immune responses that ultimately lead to tissue destruction.
Th17 immunity is now beginning to be appreciated as a set of responses mediated not only by CD4 Th17 cells but a variety of immune cells and a plethora of cytokines that collaborate to mediate immune disorders, including transplant rejection. Development and contribution of de-novo autoimmunity to chronic rejection is increasingly appreciated. The developmental plasticity of Tregs and Th17 cells is a major hurdle to Treg-based cellular therapies for transplantation. Several biologics targeting Th17 immunity are under evaluation for autoimmune disease. It remains to be determined whether these can be used in transplantation to improve outcomes. |
| doi_str_mv | 10.1097/MOT.0b013e32834ef4e4 |
| format | Article |
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Interleukin17 (IL-17) is produced by a wide variety of immune and non-immune cells in response to injury. IL-17 production by tubular epithelial cells in response to complement activation in acute antibody-mediated rejection may perpetuate immune injury. Th17-dependent de-novo autoimmunity contributes to chronic allograft rejection. Targeting IL-17 not only inhibits Th17 immunity but also attenuates Th1 immunity by affecting the initial recruitment of immune cells to sites of inflammation and modulates innate and adaptive immune responses that ultimately lead to tissue destruction.
Th17 immunity is now beginning to be appreciated as a set of responses mediated not only by CD4 Th17 cells but a variety of immune cells and a plethora of cytokines that collaborate to mediate immune disorders, including transplant rejection. Development and contribution of de-novo autoimmunity to chronic rejection is increasingly appreciated. The developmental plasticity of Tregs and Th17 cells is a major hurdle to Treg-based cellular therapies for transplantation. Several biologics targeting Th17 immunity are under evaluation for autoimmune disease. It remains to be determined whether these can be used in transplantation to improve outcomes.</description><identifier>ISSN: 1087-2418</identifier><identifier>EISSN: 1531-7013</identifier><identifier>DOI: 10.1097/MOT.0b013e32834ef4e4</identifier><identifier>PMID: 22186097</identifier><language>eng</language><publisher>United States</publisher><subject>Acute Disease ; Autoimmunity ; CD4-Positive T-Lymphocytes - immunology ; CD8-Positive T-Lymphocytes - immunology ; Chronic Disease ; Graft Rejection - immunology ; Graft Rejection - prevention & control ; Humans ; Immunosuppressive Agents - therapeutic use ; Interleukin-17 - immunology ; Receptors, Antigen, T-Cell, gamma-delta ; T-Lymphocytes, Regulatory - immunology ; Th17 Cells - drug effects ; Th17 Cells - immunology ; Transplantation Tolerance - drug effects ; Transplantation Tolerance - immunology ; Transplantation, Homologous - immunology</subject><ispartof>Current opinion in organ transplantation, 2012-02, Vol.17 (1), p.8-14</ispartof><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-61d6d3e19e38c828f26e855719a5e6bfd53bd5a4c81b7caac0df53190fb18d443</citedby><cites>FETCH-LOGICAL-c403t-61d6d3e19e38c828f26e855719a5e6bfd53bd5a4c81b7caac0df53190fb18d443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22186097$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abadja, Farida</creatorcontrib><creatorcontrib>Sarraj, Bara</creatorcontrib><creatorcontrib>Ansari, Mohammed J</creatorcontrib><title>Significance of T helper 17 immunity in transplantation</title><title>Current opinion in organ transplantation</title><addtitle>Curr Opin Organ Transplant</addtitle><description>The aim of this review is to provide an overview of significance of T helper 17 (Th17) immunity in acute, chronic and antibody-mediated allograft rejection. The role of Th17 immunity in development of de-novo autoimmunity following transplantation is outlined. It will also consider the impact of Th17 immunity on transplantation tolerance. Potential therapies to target Th17 immunity are discussed.
Interleukin17 (IL-17) is produced by a wide variety of immune and non-immune cells in response to injury. IL-17 production by tubular epithelial cells in response to complement activation in acute antibody-mediated rejection may perpetuate immune injury. Th17-dependent de-novo autoimmunity contributes to chronic allograft rejection. Targeting IL-17 not only inhibits Th17 immunity but also attenuates Th1 immunity by affecting the initial recruitment of immune cells to sites of inflammation and modulates innate and adaptive immune responses that ultimately lead to tissue destruction.
Th17 immunity is now beginning to be appreciated as a set of responses mediated not only by CD4 Th17 cells but a variety of immune cells and a plethora of cytokines that collaborate to mediate immune disorders, including transplant rejection. Development and contribution of de-novo autoimmunity to chronic rejection is increasingly appreciated. The developmental plasticity of Tregs and Th17 cells is a major hurdle to Treg-based cellular therapies for transplantation. Several biologics targeting Th17 immunity are under evaluation for autoimmune disease. It remains to be determined whether these can be used in transplantation to improve outcomes.</description><subject>Acute Disease</subject><subject>Autoimmunity</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>Chronic Disease</subject><subject>Graft Rejection - immunology</subject><subject>Graft Rejection - prevention & control</subject><subject>Humans</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Interleukin-17 - immunology</subject><subject>Receptors, Antigen, T-Cell, gamma-delta</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>Th17 Cells - drug effects</subject><subject>Th17 Cells - immunology</subject><subject>Transplantation Tolerance - drug effects</subject><subject>Transplantation Tolerance - immunology</subject><subject>Transplantation, Homologous - immunology</subject><issn>1087-2418</issn><issn>1531-7013</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkDFPwzAQhS0EoqXwDxDKxpTis53EGVFFAamoA2W2HOcMRokT4mTov8eohYHpTqf33t19hFwDXQIti7uX7W5JKwocOZNcoBUoTsgcMg5pEcensaeySJkAOSMXIXxSCqwEek5mjIHMY8icFK_u3TvrjPYGk84mu-QDmx6HBIrEte3k3bhPnE_GQfvQN9qPenSdvyRnVjcBr451Qd7WD7vVU7rZPj6v7jepEZSPaQ51XnOEErk0kknLcpRZVkCpM8wrW2e8qjMtjISqMFobWtv4QEltBbIWgi_I7SG3H7qvCcOoWhcMNvEQ7KagSshBlIxDVIqD0gxdCANa1Q-u1cNeAVU_xFQkpv4Ti7ab44KparH-M_0i4t_zAWe2</recordid><startdate>201202</startdate><enddate>201202</enddate><creator>Abadja, Farida</creator><creator>Sarraj, Bara</creator><creator>Ansari, Mohammed J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201202</creationdate><title>Significance of T helper 17 immunity in transplantation</title><author>Abadja, Farida ; Sarraj, Bara ; Ansari, Mohammed J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-61d6d3e19e38c828f26e855719a5e6bfd53bd5a4c81b7caac0df53190fb18d443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Acute Disease</topic><topic>Autoimmunity</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>Chronic Disease</topic><topic>Graft Rejection - immunology</topic><topic>Graft Rejection - prevention & control</topic><topic>Humans</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Interleukin-17 - immunology</topic><topic>Receptors, Antigen, T-Cell, gamma-delta</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><topic>Th17 Cells - drug effects</topic><topic>Th17 Cells - immunology</topic><topic>Transplantation Tolerance - drug effects</topic><topic>Transplantation Tolerance - immunology</topic><topic>Transplantation, Homologous - immunology</topic><toplevel>online_resources</toplevel><creatorcontrib>Abadja, Farida</creatorcontrib><creatorcontrib>Sarraj, Bara</creatorcontrib><creatorcontrib>Ansari, Mohammed J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current opinion in organ transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abadja, Farida</au><au>Sarraj, Bara</au><au>Ansari, Mohammed J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Significance of T helper 17 immunity in transplantation</atitle><jtitle>Current opinion in organ transplantation</jtitle><addtitle>Curr Opin Organ Transplant</addtitle><date>2012-02</date><risdate>2012</risdate><volume>17</volume><issue>1</issue><spage>8</spage><epage>14</epage><pages>8-14</pages><issn>1087-2418</issn><eissn>1531-7013</eissn><abstract>The aim of this review is to provide an overview of significance of T helper 17 (Th17) immunity in acute, chronic and antibody-mediated allograft rejection. The role of Th17 immunity in development of de-novo autoimmunity following transplantation is outlined. It will also consider the impact of Th17 immunity on transplantation tolerance. Potential therapies to target Th17 immunity are discussed.
Interleukin17 (IL-17) is produced by a wide variety of immune and non-immune cells in response to injury. IL-17 production by tubular epithelial cells in response to complement activation in acute antibody-mediated rejection may perpetuate immune injury. Th17-dependent de-novo autoimmunity contributes to chronic allograft rejection. Targeting IL-17 not only inhibits Th17 immunity but also attenuates Th1 immunity by affecting the initial recruitment of immune cells to sites of inflammation and modulates innate and adaptive immune responses that ultimately lead to tissue destruction.
Th17 immunity is now beginning to be appreciated as a set of responses mediated not only by CD4 Th17 cells but a variety of immune cells and a plethora of cytokines that collaborate to mediate immune disorders, including transplant rejection. Development and contribution of de-novo autoimmunity to chronic rejection is increasingly appreciated. The developmental plasticity of Tregs and Th17 cells is a major hurdle to Treg-based cellular therapies for transplantation. Several biologics targeting Th17 immunity are under evaluation for autoimmune disease. It remains to be determined whether these can be used in transplantation to improve outcomes.</abstract><cop>United States</cop><pmid>22186097</pmid><doi>10.1097/MOT.0b013e32834ef4e4</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1087-2418 |
| ispartof | Current opinion in organ transplantation, 2012-02, Vol.17 (1), p.8-14 |
| issn | 1087-2418 1531-7013 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Acute Disease Autoimmunity CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Chronic Disease Graft Rejection - immunology Graft Rejection - prevention & control Humans Immunosuppressive Agents - therapeutic use Interleukin-17 - immunology Receptors, Antigen, T-Cell, gamma-delta T-Lymphocytes, Regulatory - immunology Th17 Cells - drug effects Th17 Cells - immunology Transplantation Tolerance - drug effects Transplantation Tolerance - immunology Transplantation, Homologous - immunology |
| title | Significance of T helper 17 immunity in transplantation |
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