Live Cell Luminescence Imaging As a Function of Delivery Mechanism

Mitochondria in live cells can be imaged with a ruthenium(II) complex that usually binds and images nuclear DNA. The cellular uptake mechanism of this probe was changed by using a biocompatible pH‐sensitive polymersome vector. This change in delivery route, determines the final cellular location of...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2011-03, Vol.12 (4), p.548-551
Hauptverfasser:	Tian, Xiaohe, Gill, Martin R, Cantón, Irene, Thomas, Jim A, Battaglia, Giuseppe
Format:	Artikel
Sprache:	eng
Schlagworte:	bioinorganic chemistry Biological Transport Cell Line, Tumor cellular imaging confocal microscopy DNA - chemistry Humans intercellular delivery Luminescence Microscopy, Confocal Microscopy, Electron, Transmission Molecular Imaging Molecular Structure Organometallic Compounds - chemistry Organometallic Compounds - metabolism polymersomes ruthenium Ruthenium - chemistry Ruthenium - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Mitochondria in live cells can be imaged with a ruthenium(II) complex that usually binds and images nuclear DNA. The cellular uptake mechanism of this probe was changed by using a biocompatible pH‐sensitive polymersome vector. This change in delivery route, determines the final cellular location of the probe and thus modulates its imaging properties.
ISSN:	1439-4227 1439-7633
DOI:	10.1002/cbic.201000743