Sulfo-click reaction via in situ generated thioacids and its application in kinetic target-guided synthesis

Sulfo-click reaction via in situ generated thioacids and its application in kinetic target-guided synthesis

Herein, we describe a practical, one-pot variant of the sulfo-click reaction, in which 9-fluorenylmethyl-protected thioesters are rapidly deprotected and reacted further with sulfonylazides to give N-acyl sulfonamides.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2012-01, Vol.48 (10), p.1526-1528
Hauptverfasser: Namelikonda, Niranjan Kumar, Manetsch, Roman
Format: Artikel
Sprache:eng
Schlagworte:
Azides - chemistry
Click Chemistry
Esters - chemical synthesis
Esters - chemistry
Kinetics
Molecular Structure
Sulfhydryl Compounds - chemistry
Sulfonamides - chemical synthesis
Sulfonamides - chemistry
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Beschreibung
Zusammenfassung:Herein, we describe a practical, one-pot variant of the sulfo-click reaction, in which 9-fluorenylmethyl-protected thioesters are rapidly deprotected and reacted further with sulfonylazides to give N-acyl sulfonamides.
ISSN:1359-7345
1364-548X
DOI:10.1039/c1cc14724b