Hyperbranched polymers for molecular imaging: designing polymers for parahydrogen induced polarisation (PHIP)

Hyperbranched polymers for molecular imaging: designing polymers for parahydrogen induced polarisation (PHIP)

The first hyperpolarisation of polymers using parahydrogen induced polarisation (PHIP) is reported by hydrogenation of terminal alkyne groups in a biocompatible hyperbranched polymer. Signal enhancements of 1500-fold could be obtained depending on the structure of the polymer, thus opening new poten...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2012-01, Vol.48 (10), p.1583-1585
Hauptverfasser: Münnemann, Kerstin, Kölzer, Michael, Blakey, Idriss, Whittaker, Andrew K, Thurecht, Kristofer J
Format: Artikel
Sprache:eng
Schlagworte:
Alkynes
Alkynes - chemistry
Biocompatibility
Hydrogenation
Imaging
Molecular Imaging
Molecular Structure
Polymers
Polymers - chemical synthesis
Polymers - chemistry
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Zusammenfassung:The first hyperpolarisation of polymers using parahydrogen induced polarisation (PHIP) is reported by hydrogenation of terminal alkyne groups in a biocompatible hyperbranched polymer. Signal enhancements of 1500-fold could be obtained depending on the structure of the polymer, thus opening new potential avenues for polymeric molecular imaging.
ISSN:1359-7345
1364-548X
DOI:10.1039/c1cc16077j