Time Course of Histone Deacetylase 1 and Acetylated H3 and H4 Histones in the Brain of Rats Treated with Ladasten

We studied the effects of single intragastric administration of ladasten in a dose of 50 mg/kg on the time course of histone deacetylase 1 (HDAC1) and levels of acetylated histones H3 (Lys9) and H4 (Lys8) in the striatum, hippocampus, and hypothalamus. Ladasten reduced HDAC1 level in rat striatum an...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2011-03, Vol.150 (5), p.603-606
Hauptverfasser:	Salimgareeva, M. Kh, Sadovnikov, S. V., Yamidanov, R. S., Vakhitova, Yu. V., Seredenin, S. B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Adamantane - administration & dosage Adamantane - analogs & derivatives Adamantane - pharmacology Animals Biomedical and Life Sciences Biomedicine Brain Brain - drug effects Brain - metabolism Cell Biology Chromatin - drug effects Chromatin - metabolism Corpus Striatum - drug effects Corpus Striatum - metabolism DNA binding proteins Gene Expression Regulation - drug effects Genetic transcription Hippocampus Hippocampus - drug effects Hippocampus - metabolism Histone deacetylase Histone Deacetylase 1 - metabolism Histone H3 Histones Histones - metabolism Hypothalamus - drug effects Hypothalamus - metabolism Internal Medicine Laboratory Medicine Male Neostriatum Pathology Pharmacology and Toxicology Protein Processing, Post-Translational Rats
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