Time Course of Histone Deacetylase 1 and Acetylated H3 and H4 Histones in the Brain of Rats Treated with Ladasten

Time Course of Histone Deacetylase 1 and Acetylated H3 and H4 Histones in the Brain of Rats Treated with Ladasten

We studied the effects of single intragastric administration of ladasten in a dose of 50 mg/kg on the time course of histone deacetylase 1 (HDAC1) and levels of acetylated histones H3 (Lys9) and H4 (Lys8) in the striatum, hippocampus, and hypothalamus. Ladasten reduced HDAC1 level in rat striatum an...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2011-03, Vol.150 (5), p.603-606
Hauptverfasser: Salimgareeva, M. Kh, Sadovnikov, S. V., Yamidanov, R. S., Vakhitova, Yu. V., Seredenin, S. B.
Format: Artikel
Sprache:eng
Schlagworte:
Acetylation
Adamantane - administration & dosage
Adamantane - analogs & derivatives
Adamantane - pharmacology
Animals
Biomedical and Life Sciences
Biomedicine
Brain
Brain - drug effects
Brain - metabolism
Cell Biology
Chromatin - drug effects
Chromatin - metabolism
Corpus Striatum - drug effects
Corpus Striatum - metabolism
DNA binding proteins
Gene Expression Regulation - drug effects
Genetic transcription
Hippocampus
Hippocampus - drug effects
Hippocampus - metabolism
Histone deacetylase
Histone Deacetylase 1 - metabolism
Histone H3
Histones
Histones - metabolism
Hypothalamus - drug effects
Hypothalamus - metabolism
Internal Medicine
Laboratory Medicine
Male
Neostriatum
Pathology
Pharmacology and Toxicology
Protein Processing, Post-Translational
Rats
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Beschreibung
Zusammenfassung:We studied the effects of single intragastric administration of ladasten in a dose of 50 mg/kg on the time course of histone deacetylase 1 (HDAC1) and levels of acetylated histones H3 (Lys9) and H4 (Lys8) in the striatum, hippocampus, and hypothalamus. Ladasten reduced HDAC1 level in rat striatum and hippocampus and modifi ed H3acK9 and H4acK8 levels in various structures of rat brain.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-011-1201-7