Effects of Expression of Transcriptional Factor AP-1 FOSL1 Gene on Psoriatic Process

We performed quantitative analysis of FOSL1 gene expression in lesional psoriatic skin. The expression of this gene in lesional psoriatic skin was significantly increased compared to that in unaffected areas. Enhanced FOSL1 expression significantly correlated with high psoriasis area and severity in...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2011-03, Vol.150 (5), p.632-634
Hauptverfasser:	Sobolev, V. V., Zolotorenko, A. D., Soboleva, A. G., Elkin, A. M., Il’ina, S. A., Serov, D. N., Potekaev, N. N., Tkachenko, S. B., Minnibaev, M. T., Piruzyan, A. L.
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Schlagworte:	Biomedical and Life Sciences Biomedicine Cell Biology Genes Genetic aspects Genetic transcription Genetics Humans Internal Medicine Laboratory Medicine Pathology Protein binding Proteins Proto-Oncogene Proteins c-fos - metabolism Psoriasis Psoriasis - genetics Psoriasis - pathology RNA, Messenger - genetics RNA, Messenger - metabolism Skin - metabolism Skin - pathology Transcription Factor AP-1 - metabolism
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container_title	Bulletin of experimental biology and medicine
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creator	Sobolev, V. V. Zolotorenko, A. D. Soboleva, A. G. Elkin, A. M. Il’ina, S. A. Serov, D. N. Potekaev, N. N. Tkachenko, S. B. Minnibaev, M. T. Piruzyan, A. L.
description	We performed quantitative analysis of FOSL1 gene expression in lesional psoriatic skin. The expression of this gene in lesional psoriatic skin was significantly increased compared to that in unaffected areas. Enhanced FOSL1 expression significantly correlated with high psoriasis area and severity index (PASI). High level of FOSL1 gene expression was proposed to be a marker of pathological process activity in psoriasis.
doi_str_mv	10.1007/s10517-011-1208-0
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V. ; Zolotorenko, A. D. ; Soboleva, A. G. ; Elkin, A. M. ; Il’ina, S. A. ; Serov, D. N. ; Potekaev, N. N. ; Tkachenko, S. B. ; Minnibaev, M. T. ; Piruzyan, A. L.</creator><creatorcontrib>Sobolev, V. V. ; Zolotorenko, A. D. ; Soboleva, A. G. ; Elkin, A. M. ; Il’ina, S. A. ; Serov, D. N. ; Potekaev, N. N. ; Tkachenko, S. B. ; Minnibaev, M. T. ; Piruzyan, A. L.</creatorcontrib><description>We performed quantitative analysis of FOSL1 gene expression in lesional psoriatic skin. The expression of this gene in lesional psoriatic skin was significantly increased compared to that in unaffected areas. Enhanced FOSL1 expression significantly correlated with high psoriasis area and severity index (PASI). High level of FOSL1 gene expression was proposed to be a marker of pathological process activity in psoriasis.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-011-1208-0</identifier><identifier>PMID: 22235402</identifier><identifier>CODEN: BEXBAN</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Genes ; Genetic aspects ; Genetic transcription ; Genetics ; Humans ; Internal Medicine ; Laboratory Medicine ; Pathology ; Protein binding ; Proteins ; Proto-Oncogene Proteins c-fos - metabolism ; Psoriasis ; Psoriasis - genetics ; Psoriasis - pathology ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Skin - metabolism ; Skin - pathology ; Transcription Factor AP-1 - metabolism</subject><ispartof>Bulletin of experimental biology and medicine, 2011-03, Vol.150 (5), p.632-634</ispartof><rights>Springer Science+Business Media, Inc. 2011</rights><rights>COPYRIGHT 2011 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c501t-6aa64422c6afd5b0a06c3b145786d68b27813111737d3bef6714dd370ed0c5b13</citedby><cites>FETCH-LOGICAL-c501t-6aa64422c6afd5b0a06c3b145786d68b27813111737d3bef6714dd370ed0c5b13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-011-1208-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-011-1208-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22235402$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sobolev, V. 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Enhanced FOSL1 expression significantly correlated with high psoriasis area and severity index (PASI). High level of FOSL1 gene expression was proposed to be a marker of pathological process activity in psoriasis.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>22235402</pmid><doi>10.1007/s10517-011-1208-0</doi><tpages>3</tpages></addata></record>
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subjects	Biomedical and Life Sciences Biomedicine Cell Biology Genes Genetic aspects Genetic transcription Genetics Humans Internal Medicine Laboratory Medicine Pathology Protein binding Proteins Proto-Oncogene Proteins c-fos - metabolism Psoriasis Psoriasis - genetics Psoriasis - pathology RNA, Messenger - genetics RNA, Messenger - metabolism Skin - metabolism Skin - pathology Transcription Factor AP-1 - metabolism
title	Effects of Expression of Transcriptional Factor AP-1 FOSL1 Gene on Psoriatic Process
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