Effects of Expression of Transcriptional Factor AP-1 FOSL1 Gene on Psoriatic Process

Effects of Expression of Transcriptional Factor AP-1 FOSL1 Gene on Psoriatic Process

We performed quantitative analysis of FOSL1 gene expression in lesional psoriatic skin. The expression of this gene in lesional psoriatic skin was significantly increased compared to that in unaffected areas. Enhanced FOSL1 expression significantly correlated with high psoriasis area and severity in...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2011-03, Vol.150 (5), p.632-634
Hauptverfasser: Sobolev, V. V., Zolotorenko, A. D., Soboleva, A. G., Elkin, A. M., Il’ina, S. A., Serov, D. N., Potekaev, N. N., Tkachenko, S. B., Minnibaev, M. T., Piruzyan, A. L.
Format: Artikel
Sprache:eng
Schlagworte:
Biomedical and Life Sciences
Biomedicine
Cell Biology
Genes
Genetic aspects
Genetic transcription
Genetics
Humans
Internal Medicine
Laboratory Medicine
Pathology
Protein binding
Proteins
Proto-Oncogene Proteins c-fos - metabolism
Psoriasis
Psoriasis - genetics
Psoriasis - pathology
RNA, Messenger - genetics
RNA, Messenger - metabolism
Skin - metabolism
Skin - pathology
Transcription Factor AP-1 - metabolism
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Zusammenfassung:We performed quantitative analysis of FOSL1 gene expression in lesional psoriatic skin. The expression of this gene in lesional psoriatic skin was significantly increased compared to that in unaffected areas. Enhanced FOSL1 expression significantly correlated with high psoriasis area and severity index (PASI). High level of FOSL1 gene expression was proposed to be a marker of pathological process activity in psoriasis.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-011-1208-0