Microbiota in autoimmunity and tolerance

Microbiota in autoimmunity and tolerance

Highlights ► Intestinal microbiota affects T cell differentiation and thereby host susceptibility to autoimmune disease. ► SFB induce the accumulation of Th17 cells in the small intestinal lamina propria. ► Intestinal Th17 cells induced by SFB affect the local and systemic autoimmune and inflammator...

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Veröffentlicht in:Current opinion in immunology 2011-12, Vol.23 (6), p.761-768
Hauptverfasser: Atarashi, Koji, Honda, Kenya
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Animals
Autoimmune Diseases - immunology
Autoimmunity
Humans
Immune Tolerance
Intestines - immunology
Intestines - microbiology
Metagenome
T-Lymphocytes - cytology
T-Lymphocytes - immunology
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Beschreibung
Zusammenfassung:Highlights ► Intestinal microbiota affects T cell differentiation and thereby host susceptibility to autoimmune disease. ► SFB induce the accumulation of Th17 cells in the small intestinal lamina propria. ► Intestinal Th17 cells induced by SFB affect the local and systemic autoimmune and inflammatory diseases. ► The number of colonic Treg cells is affected by the microbiota, particularly by Clostridium species. ► Treg cells induced by Clostridium species affect autoimmunity and tolerance.
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2011.11.002