The role of bioreductive activation of antitumour anthracycline drugs in cytotoxic activity against sensitive and multidrug resistant leukaemia HL60 cells

Clinical usefulness of anthracyclines belonging to bioreductive antitumour drugs is limited by the occurrence of multidrug resistance (MDR). The aim of this study was to examine the role of structural factors of antitumour anthracycline drugs in the ability to undergo bioreductive activation by NADP...

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Veröffentlicht in:European journal of pharmacology 2012-01, Vol.674 (2-3), p.112-125
Hauptverfasser: Kostrzewa-Nowak, Dorota, Bieg, Bohdan, Paine, Mark J.I., Wolf, C. Roland, Tarasiuk, Jolanta
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Sprache:eng
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