The LIM domain protein, CRIP2, promotes apoptosis in esophageal squamous cell carcinoma
Abstract The group 2 LIM domain protein, Cysteine-rich intestinal protein 2 (CRIP2) was found to play an important role in esophageal squamous cell carcinoma (ESCC) tumorigenesis. Subcellular fractionation studies show that CRIP2 is expressed in the nucleus. Real-time quantitative PCR shows CRIP2 ex...
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| Veröffentlicht in: | Cancer letters 2012-03, Vol.316 (1), p.39-45 |
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| container_title | Cancer letters |
| container_volume | 316 |
| creator | Lo, Paulisally Hau Yi Ko, Josephine Mun Yee Yu, Zhuo You Law, Simon Wang, Li Dong Li, Ji-Lin Srivastava, Gopesh Tsao, Sai Wah Stanbridge, Eric J Lung, Maria Li |
| description | Abstract The group 2 LIM domain protein, Cysteine-rich intestinal protein 2 (CRIP2) was found to play an important role in esophageal squamous cell carcinoma (ESCC) tumorigenesis. Subcellular fractionation studies show that CRIP2 is expressed in the nucleus. Real-time quantitative PCR shows CRIP2 expression is down-regulated in ESCC tissues and cell lines. Functional studies reveal that CRIP2 reduces colony formation, growth, and invasion abilities. Furthermore, over-expression of CRIP2 induces apoptosis through induction of active caspases 3 and 9 proteins. In conclusion, this study shows CRIP2 plays an important role in the development of ESCC. |
| doi_str_mv | 10.1016/j.canlet.2011.10.020 |
| format | Article |
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Subcellular fractionation studies show that CRIP2 is expressed in the nucleus. Real-time quantitative PCR shows CRIP2 expression is down-regulated in ESCC tissues and cell lines. Functional studies reveal that CRIP2 reduces colony formation, growth, and invasion abilities. Furthermore, over-expression of CRIP2 induces apoptosis through induction of active caspases 3 and 9 proteins. In conclusion, this study shows CRIP2 plays an important role in the development of ESCC.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/j.canlet.2011.10.020</identifier><identifier>PMID: 22154084</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Adaptor Proteins, Signal Transducing - genetics ; Adaptor Proteins, Signal Transducing - metabolism ; Animals ; Apoptosis ; Apoptosis - genetics ; carcinogenesis ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - pathology ; Caspase 3 - metabolism ; Caspase 9 - metabolism ; caspases ; Cell culture ; Cell cycle ; Cell growth ; Cell Growth Processes - genetics ; Cell Line, Tumor ; Cell Nucleus - genetics ; Cell Nucleus - metabolism ; Cell Transformation, Neoplastic - genetics ; Cell Transformation, Neoplastic - metabolism ; Chromosomes ; Cloning ; CRIP2 ; Down-Regulation ; Esophageal Neoplasms - genetics ; Esophageal Neoplasms - metabolism ; Esophageal Neoplasms - pathology ; Esophageal squamous cell carcinoma ; Female ; Flow cytometry ; fractionation ; Gene expression ; gene expression regulation ; Hematology, Oncology and Palliative Medicine ; Humans ; LIM Domain Proteins - genetics ; LIM Domain Proteins - metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Neoplasm Invasiveness - genetics ; Proteins ; quantitative polymerase chain reaction ; Real-Time Polymerase Chain Reaction - methods ; squamous cell carcinoma ; Statistical analysis ; Studies ; Tumorigenesis ; Tumors ; Up-Regulation</subject><ispartof>Cancer letters, 2012-03, Vol.316 (1), p.39-45</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2011 Elsevier Ireland Ltd</rights><rights>Copyright © 2011 Elsevier Ireland Ltd. 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Subcellular fractionation studies show that CRIP2 is expressed in the nucleus. Real-time quantitative PCR shows CRIP2 expression is down-regulated in ESCC tissues and cell lines. Functional studies reveal that CRIP2 reduces colony formation, growth, and invasion abilities. Furthermore, over-expression of CRIP2 induces apoptosis through induction of active caspases 3 and 9 proteins. In conclusion, this study shows CRIP2 plays an important role in the development of ESCC.</description><subject>Adaptor Proteins, Signal Transducing - genetics</subject><subject>Adaptor Proteins, Signal Transducing - metabolism</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Apoptosis - genetics</subject><subject>carcinogenesis</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Caspase 3 - metabolism</subject><subject>Caspase 9 - metabolism</subject><subject>caspases</subject><subject>Cell culture</subject><subject>Cell cycle</subject><subject>Cell growth</subject><subject>Cell Growth Processes - genetics</subject><subject>Cell Line, Tumor</subject><subject>Cell Nucleus - genetics</subject><subject>Cell Nucleus - metabolism</subject><subject>Cell Transformation, Neoplastic - genetics</subject><subject>Cell Transformation, Neoplastic - metabolism</subject><subject>Chromosomes</subject><subject>Cloning</subject><subject>CRIP2</subject><subject>Down-Regulation</subject><subject>Esophageal Neoplasms - genetics</subject><subject>Esophageal Neoplasms - metabolism</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophageal squamous cell carcinoma</subject><subject>Female</subject><subject>Flow cytometry</subject><subject>fractionation</subject><subject>Gene expression</subject><subject>gene expression regulation</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>LIM Domain Proteins - genetics</subject><subject>LIM Domain Proteins - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Nude</subject><subject>Neoplasm Invasiveness - genetics</subject><subject>Proteins</subject><subject>quantitative polymerase chain reaction</subject><subject>Real-Time Polymerase Chain Reaction - methods</subject><subject>squamous cell carcinoma</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Tumorigenesis</subject><subject>Tumors</subject><subject>Up-Regulation</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkltrFEEQhRtRzBr9B6IDPviSWatv07MvAVm8LKwoJsHHpranJul1bumeEfLv7WGiQl58aqr46nDqdDH2ksOaAy_eHdcOu4bGtQDOU2sNAh6xFS-NyM2mhMdsBRJULkupT9izGI8AoJXRT9mJEFwrKNWK_bi8oWy_-5JVfYu-y4bQj-S7s2z7ffdNnM11mzoxw6Efxj76mCWKYj_c4DVhk8XbCdt-ipmjpskcBue7JPWcPamxifTi_j1lVx8_XG4_5_uvn3bb9_vcqaIcc5RKI5HTuNGyMg6LEuqDqCuFUJHRldTiICUphYnBkpPhlGpjsDB1WctT9nbRTUZvJ4qjbX2crWBHyZXdcA0KRFEm8s0D8thPoUvmbGIKMEromVIL5UIfY6DaDsG3GO4sBzvnbo92yd3Ouc_dlHsae3UvPh1aqv4O_Qk6Aa8XoMbe4nXw0V5dJAWdPkWKjZCJOF8ISnH98hRsdJ46R5UP5EZb9f5_Hh4KuMZ33mHzk-4o_tvWRmHBXszXMR8H5wCFNBv5G2fEsrQ</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Lo, Paulisally Hau Yi</creator><creator>Ko, Josephine Mun Yee</creator><creator>Yu, Zhuo You</creator><creator>Law, Simon</creator><creator>Wang, Li Dong</creator><creator>Li, Ji-Lin</creator><creator>Srivastava, Gopesh</creator><creator>Tsao, Sai Wah</creator><creator>Stanbridge, Eric J</creator><creator>Lung, Maria Li</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Limited</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20120301</creationdate><title>The LIM domain protein, CRIP2, promotes apoptosis in esophageal squamous cell carcinoma</title><author>Lo, Paulisally Hau Yi ; Ko, Josephine Mun Yee ; Yu, Zhuo You ; Law, Simon ; Wang, Li Dong ; Li, Ji-Lin ; Srivastava, Gopesh ; Tsao, Sai Wah ; Stanbridge, Eric J ; Lung, Maria Li</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-a345aeec5a953d7ca680fb2fd4a0de75d352b33e44ac5aa81e71e33e77a67f8f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adaptor Proteins, Signal Transducing - genetics</topic><topic>Adaptor Proteins, Signal Transducing - metabolism</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Apoptosis - genetics</topic><topic>carcinogenesis</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Caspase 3 - metabolism</topic><topic>Caspase 9 - metabolism</topic><topic>caspases</topic><topic>Cell culture</topic><topic>Cell cycle</topic><topic>Cell growth</topic><topic>Cell Growth Processes - genetics</topic><topic>Cell Line, Tumor</topic><topic>Cell Nucleus - genetics</topic><topic>Cell Nucleus - metabolism</topic><topic>Cell Transformation, Neoplastic - genetics</topic><topic>Cell Transformation, Neoplastic - metabolism</topic><topic>Chromosomes</topic><topic>Cloning</topic><topic>CRIP2</topic><topic>Down-Regulation</topic><topic>Esophageal Neoplasms - genetics</topic><topic>Esophageal Neoplasms - metabolism</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Esophageal squamous cell carcinoma</topic><topic>Female</topic><topic>Flow cytometry</topic><topic>fractionation</topic><topic>Gene expression</topic><topic>gene expression regulation</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>LIM Domain Proteins - genetics</topic><topic>LIM Domain Proteins - metabolism</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Nude</topic><topic>Neoplasm Invasiveness - genetics</topic><topic>Proteins</topic><topic>quantitative polymerase chain reaction</topic><topic>Real-Time Polymerase Chain Reaction - methods</topic><topic>squamous cell carcinoma</topic><topic>Statistical analysis</topic><topic>Studies</topic><topic>Tumorigenesis</topic><topic>Tumors</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lo, Paulisally Hau Yi</creatorcontrib><creatorcontrib>Ko, Josephine Mun Yee</creatorcontrib><creatorcontrib>Yu, Zhuo You</creatorcontrib><creatorcontrib>Law, Simon</creatorcontrib><creatorcontrib>Wang, Li Dong</creatorcontrib><creatorcontrib>Li, Ji-Lin</creatorcontrib><creatorcontrib>Srivastava, Gopesh</creatorcontrib><creatorcontrib>Tsao, Sai Wah</creatorcontrib><creatorcontrib>Stanbridge, Eric J</creatorcontrib><creatorcontrib>Lung, Maria Li</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lo, Paulisally Hau Yi</au><au>Ko, Josephine Mun Yee</au><au>Yu, Zhuo You</au><au>Law, Simon</au><au>Wang, Li Dong</au><au>Li, Ji-Lin</au><au>Srivastava, Gopesh</au><au>Tsao, Sai Wah</au><au>Stanbridge, Eric J</au><au>Lung, Maria Li</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The LIM domain protein, CRIP2, promotes apoptosis in esophageal squamous cell carcinoma</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>316</volume><issue>1</issue><spage>39</spage><epage>45</epage><pages>39-45</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>Abstract The group 2 LIM domain protein, Cysteine-rich intestinal protein 2 (CRIP2) was found to play an important role in esophageal squamous cell carcinoma (ESCC) tumorigenesis. Subcellular fractionation studies show that CRIP2 is expressed in the nucleus. Real-time quantitative PCR shows CRIP2 expression is down-regulated in ESCC tissues and cell lines. Functional studies reveal that CRIP2 reduces colony formation, growth, and invasion abilities. Furthermore, over-expression of CRIP2 induces apoptosis through induction of active caspases 3 and 9 proteins. In conclusion, this study shows CRIP2 plays an important role in the development of ESCC.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>22154084</pmid><doi>10.1016/j.canlet.2011.10.020</doi><tpages>7</tpages></addata></record> |
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| ispartof | Cancer letters, 2012-03, Vol.316 (1), p.39-45 |
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| subjects | Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Apoptosis Apoptosis - genetics carcinogenesis Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Caspase 3 - metabolism Caspase 9 - metabolism caspases Cell culture Cell cycle Cell growth Cell Growth Processes - genetics Cell Line, Tumor Cell Nucleus - genetics Cell Nucleus - metabolism Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Chromosomes Cloning CRIP2 Down-Regulation Esophageal Neoplasms - genetics Esophageal Neoplasms - metabolism Esophageal Neoplasms - pathology Esophageal squamous cell carcinoma Female Flow cytometry fractionation Gene expression gene expression regulation Hematology, Oncology and Palliative Medicine Humans LIM Domain Proteins - genetics LIM Domain Proteins - metabolism Mice Mice, Inbred BALB C Mice, Nude Neoplasm Invasiveness - genetics Proteins quantitative polymerase chain reaction Real-Time Polymerase Chain Reaction - methods squamous cell carcinoma Statistical analysis Studies Tumorigenesis Tumors Up-Regulation |
| title | The LIM domain protein, CRIP2, promotes apoptosis in esophageal squamous cell carcinoma |
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