The LIM domain protein, CRIP2, promotes apoptosis in esophageal squamous cell carcinoma

Abstract The group 2 LIM domain protein, Cysteine-rich intestinal protein 2 (CRIP2) was found to play an important role in esophageal squamous cell carcinoma (ESCC) tumorigenesis. Subcellular fractionation studies show that CRIP2 is expressed in the nucleus. Real-time quantitative PCR shows CRIP2 ex...

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Veröffentlicht in:	Cancer letters 2012-03, Vol.316 (1), p.39-45
Hauptverfasser:	Lo, Paulisally Hau Yi, Ko, Josephine Mun Yee, Yu, Zhuo You, Law, Simon, Wang, Li Dong, Li, Ji-Lin, Srivastava, Gopesh, Tsao, Sai Wah, Stanbridge, Eric J, Lung, Maria Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Apoptosis Apoptosis - genetics carcinogenesis Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Caspase 3 - metabolism Caspase 9 - metabolism caspases Cell culture Cell cycle Cell growth Cell Growth Processes - genetics Cell Line, Tumor Cell Nucleus - genetics Cell Nucleus - metabolism Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Chromosomes Cloning CRIP2 Down-Regulation Esophageal Neoplasms - genetics Esophageal Neoplasms - metabolism Esophageal Neoplasms - pathology Esophageal squamous cell carcinoma Female Flow cytometry fractionation Gene expression gene expression regulation Hematology, Oncology and Palliative Medicine Humans LIM Domain Proteins - genetics LIM Domain Proteins - metabolism Mice Mice, Inbred BALB C Mice, Nude Neoplasm Invasiveness - genetics Proteins quantitative polymerase chain reaction Real-Time Polymerase Chain Reaction - methods squamous cell carcinoma Statistical analysis Studies Tumorigenesis Tumors Up-Regulation
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Zusammenfassung:	Abstract The group 2 LIM domain protein, Cysteine-rich intestinal protein 2 (CRIP2) was found to play an important role in esophageal squamous cell carcinoma (ESCC) tumorigenesis. Subcellular fractionation studies show that CRIP2 is expressed in the nucleus. Real-time quantitative PCR shows CRIP2 expression is down-regulated in ESCC tissues and cell lines. Functional studies reveal that CRIP2 reduces colony formation, growth, and invasion abilities. Furthermore, over-expression of CRIP2 induces apoptosis through induction of active caspases 3 and 9 proteins. In conclusion, this study shows CRIP2 plays an important role in the development of ESCC.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2011.10.020