Access to Quinolines through Gold-Catalyzed Intermolecular Cycloaddition of 2-Aminoaryl Carbonyls and Internal Alkynes

Access to Quinolines through Gold-Catalyzed Intermolecular Cycloaddition of 2-Aminoaryl Carbonyls and Internal Alkynes

A facile and general method leading to polyfunctionalized quinolines was developed. In the presence of a highly efficient combination encompassing (PPh)3AuCl and AgOTf, the reactions between 2-aminocarbonyls and an array of internal alkynes proceeded smoothly to afford quinoline derivatives in good...

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Veröffentlicht in:Journal of organic chemistry 2012-01, Vol.77 (1), p.801-807
Hauptverfasser: Cai, Shuting, Zeng, Jing, Bai, Yaguang, Liu, Xue-Wei
Format: Artikel
Sprache:eng
Schlagworte:
Alkynes - chemistry
Aniline Compounds - chemistry
Catalysis
Chemistry
Cyclization
Exact sciences and technology
Gold - chemistry
Heterocyclic compounds
Heterocyclic compounds with only one n hetero atom and condensed derivatives
Molecular Structure
Organic chemistry
Preparations and properties
Quinolines - chemistry
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Beschreibung
Zusammenfassung:A facile and general method leading to polyfunctionalized quinolines was developed. In the presence of a highly efficient combination encompassing (PPh)3AuCl and AgOTf, the reactions between 2-aminocarbonyls and an array of internal alkynes proceeded smoothly to afford quinoline derivatives in good to excellent yields (up to 93%).
ISSN:0022-3263
1520-6904
DOI:10.1021/jo202281x