Overexpression of Chromosome 15q11-q13 Gene Products: A Risk Factor for Schizophrenia and Associated Psychoses?

Overexpression of Chromosome 15q11-q13 Gene Products: A Risk Factor for Schizophrenia and Associated Psychoses?

We read with interest the article by Ingason et al. (1) in the April 2011 issue of the +Italic Journal -Italic . Their results suggest that the presence of an extra (maternal) copy of a fragment of chromosome 15q11-q13 that overlaps with the Prader-Willi/Angelman syndrome critical region may be a ra...

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Veröffentlicht in:The American journal of psychiatry 2012-01, Vol.169 (1), p.96-97
Hauptverfasser: Boot, Erik, Kant, Sarina G., Otter, Maarten, Cohen, Dan, Nabanizadeh, Amal, Baas, Ronald W.J.
Format: Artikel
Sprache:eng
Schlagworte:
Chromosomes
Chromosomes, Human, Pair 15 - genetics
DNA Copy Number Variations - genetics
Female
Gene expression
Humans
Male
Psychiatry
Risk factors
Schizophrenia
Schizophrenia - genetics
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Beschreibung
Zusammenfassung:We read with interest the article by Ingason et al. (1) in the April 2011 issue of the +Italic Journal -Italic . Their results suggest that the presence of an extra (maternal) copy of a fragment of chromosome 15q11-q13 that overlaps with the Prader-Willi/Angelman syndrome critical region may be a rare risk factor for schizophrenia and other psychoses.
ISSN:0002-953X
1535-7228
DOI:10.1176/appi.ajp.2011.11091382