Rhodium(III)-Catalyzed Intermolecular Direct Amination of Aromatic C–H Bonds with N-Chloroamines

Rhodium(III)-Catalyzed Intermolecular Direct Amination of Aromatic C–H Bonds with N-Chloroamines

A Rh(III)-catalyzed direct aromatic C–H amination is achieved using N-chloroamines as a reagent. Furthermore, we also developed a one-pot amination protocol involving in situ chlorination of the secondary amines. The catalytic amination operates at mild conditions with excellent functional group tol...

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Veröffentlicht in:Organic letters 2012-01, Vol.14 (1), p.272-275
Hauptverfasser: Ng, Ka-Ho, Zhou, Zhongyuan, Yu, Wing-Yiu
Format: Artikel
Sprache:eng
Schlagworte:
Amination
Carbon - chemistry
Catalysis
Chloramines - chemistry
Hydrogen - chemistry
Molecular Structure
Rhodium - chemistry
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Zusammenfassung:A Rh(III)-catalyzed direct aromatic C–H amination is achieved using N-chloroamines as a reagent. Furthermore, we also developed a one-pot amination protocol involving in situ chlorination of the secondary amines. The catalytic amination operates at mild conditions with excellent functional group tolerance and regioselectivity.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol203046n