Old World Leishmania infantum Cutaneous Leishmaniasis Unresponsive to Liposomal Amphotericin B Treated With Topical Imiquimod

We present a case of a child with Leishmania infantum cutaneous leishmaniasis unresponsive to 2 courses of intravenous liposomal amphotericin B, a treatment failure that has not been reported in this Leishmania species. The patient responded to topical imiquimod and had no relapse. We review the lit...

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Veröffentlicht in:	The Pediatric infectious disease journal 2012-01, Vol.31 (1), p.97-100
Hauptverfasser:	Hervás, Juan A, Martín-Santiago, Ana, Hervás, Daniel, Rojo, Estrella, Mena, Ana, Rocamora, Vicente, Dueñas, Joaquín
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Aminoquinolines - administration & dosage Amphotericin B - administration & dosage Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antiparasitic agents Antiprotozoal Agents - administration & dosage Biological and medical sciences Child Human protozoal diseases Humans Infectious diseases Leishmania infantum - drug effects Leishmaniasis, Cutaneous - drug therapy Leishmaniasis, Cutaneous - parasitology Leshmaniasis Liposomes - administration & dosage Male Medical sciences Parasitic diseases Pharmacology. Drug treatments Protozoal diseases Treatment Failure Treatment Outcome
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Zusammenfassung:	We present a case of a child with Leishmania infantum cutaneous leishmaniasis unresponsive to 2 courses of intravenous liposomal amphotericin B, a treatment failure that has not been reported in this Leishmania species. The patient responded to topical imiquimod and had no relapse. We review the literature on the treatment failure of liposomal amphotericin B for cutaneous leishmaniasis.
ISSN:	0891-3668 1532-0987
DOI:	10.1097/INF.0b013e31822dfbf7