Development of the first sphingomyelin biomimetic stationary phase for immobilized artificial membrane (IAM) chromatography

A prototype sphingomyelin stationary phase for Immobilized Artificial Membrane (IAM) chromatography was synthesized by an ultra-short, solid-phase inspired methodology, in which an oxidative release monitoring strategy played a vital role. Evaluated in a proof-of-concept model for blood-brain barrie...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2012-01, Vol.48 (8), p.1162-1164
Hauptverfasser:	Verzele, Dieter, Lynen, Frédéric, De Vrieze, Mike, Wright, Adrian G, Hanna-Brown, Melissa, Sandra, Pat
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomimetic Materials - chemistry Blood-Brain Barrier - metabolism Chromatography - methods Least-Squares Analysis Membranes, Artificial Oxidation-Reduction Sphingomyelins - chemistry Sphingomyelins - metabolism
Online-Zugang:	Volltext
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