Development of the first sphingomyelin biomimetic stationary phase for immobilized artificial membrane (IAM) chromatography

Development of the first sphingomyelin biomimetic stationary phase for immobilized artificial membrane (IAM) chromatography

A prototype sphingomyelin stationary phase for Immobilized Artificial Membrane (IAM) chromatography was synthesized by an ultra-short, solid-phase inspired methodology, in which an oxidative release monitoring strategy played a vital role. Evaluated in a proof-of-concept model for blood-brain barrie...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2012-01, Vol.48 (8), p.1162-1164
Hauptverfasser: Verzele, Dieter, Lynen, Frédéric, De Vrieze, Mike, Wright, Adrian G, Hanna-Brown, Melissa, Sandra, Pat
Format: Artikel
Sprache:eng
Schlagworte:
Biomimetic Materials - chemistry
Blood-Brain Barrier - metabolism
Chromatography - methods
Least-Squares Analysis
Membranes, Artificial
Oxidation-Reduction
Sphingomyelins - chemistry
Sphingomyelins - metabolism
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Zusammenfassung:A prototype sphingomyelin stationary phase for Immobilized Artificial Membrane (IAM) chromatography was synthesized by an ultra-short, solid-phase inspired methodology, in which an oxidative release monitoring strategy played a vital role. Evaluated in a proof-of-concept model for blood-brain barrier passage, partial least squares regression demonstrated its potential as an in vitro prediction tool.
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc16872c