Effects of osteoporosis and nutrition supplements on structures and nanomechanical properties of bone tissue
In this study, the bone structures, nanomechanical properties and fracture behaviors in different groups of female C57BL/6 mice (control, sham operated, ovariectomized, casein supplemented, and fermented milk supplemented) were examined by micro-computed tomography, scanning and transmission electro...
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| Veröffentlicht in: | Journal of the mechanical behavior of biomedical materials 2011-10, Vol.4 (7), p.1412-1420 |
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| creator | Chang, Yuan-Ting Chen, Chuan-Mu Tu, Min-Yu Chen, Hsiao-Ling Chang, Shou-Yi Tsai, Tung-Chou Wang, Ying-Ting Hsiao, Hsiang-Long |
| description | In this study, the bone structures, nanomechanical properties and fracture behaviors in different groups of female C57BL/6 mice (control, sham operated, ovariectomized, casein supplemented, and fermented milk supplemented) were examined by micro-computed tomography, scanning and transmission electron microscopy, and nanoindentation. The control and sham operated mice showed dense bone structures with high cortical bone mineral densities of 544 mg/cm
3 (average) and high hardness of 0.9–1.1 GPa; resistance to bone fracture was conferred by microcracking, crack deflections and ligament bridging attributed to aligned collagen fibers and densely packed hydroxyapatite crystals. Bone mineral density, hardness and fracture resistance in ovariectomized mice markedly dropped due to loose bone structure with randomly distributed collagens and hydroxyapatites. The acidic casein supplemented mice with blood acidosis exhibited poor mineral absorption and loose bone structure, whereas the neutralized casein or fermented milk supplemented mice were resistant to osteoporosis and had high bone mechanical properties.
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| doi_str_mv | 10.1016/j.jmbbm.2011.05.011 |
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3 (average) and high hardness of 0.9–1.1 GPa; resistance to bone fracture was conferred by microcracking, crack deflections and ligament bridging attributed to aligned collagen fibers and densely packed hydroxyapatite crystals. Bone mineral density, hardness and fracture resistance in ovariectomized mice markedly dropped due to loose bone structure with randomly distributed collagens and hydroxyapatites. The acidic casein supplemented mice with blood acidosis exhibited poor mineral absorption and loose bone structure, whereas the neutralized casein or fermented milk supplemented mice were resistant to osteoporosis and had high bone mechanical properties.
[Display omitted]</description><identifier>ISSN: 1751-6161</identifier><identifier>EISSN: 1878-0180</identifier><identifier>DOI: 10.1016/j.jmbbm.2011.05.011</identifier><identifier>PMID: 21783151</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Animals ; Biomechanical Phenomena ; Biomedical materials ; Bone ; Bone and Bones - diagnostic imaging ; Bone and Bones - metabolism ; Bone and Bones - pathology ; Bone and Bones - physiopathology ; Bone Density ; Bones ; Collagen - chemistry ; Collagen - metabolism ; Density ; Dietary Supplements ; Durapatite - chemistry ; Durapatite - metabolism ; Female ; Fracture mechanics ; Fractures, Bone - complications ; Mechanical Phenomena ; Mechanical property ; Mice ; Mice, Inbred C57BL ; Nanoindentation ; Nanostructure ; Nanotechnology ; Nutrition ; Osteoporosis ; Osteoporosis - complications ; Osteoporosis - metabolism ; Osteoporosis - pathology ; Osteoporosis - physiopathology ; Scanning electron microscopy ; Surgical implants ; X-Ray Microtomography</subject><ispartof>Journal of the mechanical behavior of biomedical materials, 2011-10, Vol.4 (7), p.1412-1420</ispartof><rights>2011 Elsevier Ltd</rights><rights>Copyright © 2011 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-571f0178cdc6f624e5a13482d091294d183122ef22155ffaa7b7c699f67034923</citedby><cites>FETCH-LOGICAL-c456t-571f0178cdc6f624e5a13482d091294d183122ef22155ffaa7b7c699f67034923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jmbbm.2011.05.011$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21783151$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chang, Yuan-Ting</creatorcontrib><creatorcontrib>Chen, Chuan-Mu</creatorcontrib><creatorcontrib>Tu, Min-Yu</creatorcontrib><creatorcontrib>Chen, Hsiao-Ling</creatorcontrib><creatorcontrib>Chang, Shou-Yi</creatorcontrib><creatorcontrib>Tsai, Tung-Chou</creatorcontrib><creatorcontrib>Wang, Ying-Ting</creatorcontrib><creatorcontrib>Hsiao, Hsiang-Long</creatorcontrib><title>Effects of osteoporosis and nutrition supplements on structures and nanomechanical properties of bone tissue</title><title>Journal of the mechanical behavior of biomedical materials</title><addtitle>J Mech Behav Biomed Mater</addtitle><description>In this study, the bone structures, nanomechanical properties and fracture behaviors in different groups of female C57BL/6 mice (control, sham operated, ovariectomized, casein supplemented, and fermented milk supplemented) were examined by micro-computed tomography, scanning and transmission electron microscopy, and nanoindentation. The control and sham operated mice showed dense bone structures with high cortical bone mineral densities of 544 mg/cm
3 (average) and high hardness of 0.9–1.1 GPa; resistance to bone fracture was conferred by microcracking, crack deflections and ligament bridging attributed to aligned collagen fibers and densely packed hydroxyapatite crystals. Bone mineral density, hardness and fracture resistance in ovariectomized mice markedly dropped due to loose bone structure with randomly distributed collagens and hydroxyapatites. The acidic casein supplemented mice with blood acidosis exhibited poor mineral absorption and loose bone structure, whereas the neutralized casein or fermented milk supplemented mice were resistant to osteoporosis and had high bone mechanical properties.
[Display omitted]</description><subject>Animals</subject><subject>Biomechanical Phenomena</subject><subject>Biomedical materials</subject><subject>Bone</subject><subject>Bone and Bones - diagnostic imaging</subject><subject>Bone and Bones - metabolism</subject><subject>Bone and Bones - pathology</subject><subject>Bone and Bones - physiopathology</subject><subject>Bone Density</subject><subject>Bones</subject><subject>Collagen - chemistry</subject><subject>Collagen - metabolism</subject><subject>Density</subject><subject>Dietary Supplements</subject><subject>Durapatite - chemistry</subject><subject>Durapatite - metabolism</subject><subject>Female</subject><subject>Fracture mechanics</subject><subject>Fractures, Bone - complications</subject><subject>Mechanical Phenomena</subject><subject>Mechanical property</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Nanoindentation</subject><subject>Nanostructure</subject><subject>Nanotechnology</subject><subject>Nutrition</subject><subject>Osteoporosis</subject><subject>Osteoporosis - complications</subject><subject>Osteoporosis - metabolism</subject><subject>Osteoporosis - pathology</subject><subject>Osteoporosis - physiopathology</subject><subject>Scanning electron microscopy</subject><subject>Surgical implants</subject><subject>X-Ray Microtomography</subject><issn>1751-6161</issn><issn>1878-0180</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFP3DAQha2qVaHAL6iEcuspqceJHefAASGglZB6ac-W44xVrxI72A4S_75eduFIT28sffP8NI-Qr0AboCC-75rdMo5LwyhAQ3lT5AM5BdnLmoKkH8vcc6gFCDghX1LaUSoolfIzOWHQyxY4nJL51lo0OVXBViFlDGuIIblUaT9VfsvRZRd8lbZ1nXFBvyfLM8fN5C3ikdM-LGj-au-Mnqs1hhVjdvjiOgaPVXYpbXhOPlk9J7w46hn5c3f7--ZH_fDr_ufN9UNtOi5yzXuwtCQ0kxFWsA65hraTbKIDsKGboGRnDC1jwLm1Wvdjb8QwWNHTthtYe0a-HXxLkscNU1aLSwbnWXsMW1IDdILJQbb_JWU_AO1aCoVsD6Qp90kRrVqjW3R8VkDVvg-1Uy99qH0finJVpGxdHv23ccHpbee1gAJcHQAs93hyGFUyDr3BycXSi5qCe_eDf5D1neA</recordid><startdate>20111001</startdate><enddate>20111001</enddate><creator>Chang, Yuan-Ting</creator><creator>Chen, Chuan-Mu</creator><creator>Tu, Min-Yu</creator><creator>Chen, Hsiao-Ling</creator><creator>Chang, Shou-Yi</creator><creator>Tsai, Tung-Chou</creator><creator>Wang, Ying-Ting</creator><creator>Hsiao, Hsiang-Long</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7SR</scope><scope>7TB</scope><scope>8BQ</scope><scope>8FD</scope><scope>FR3</scope><scope>JG9</scope></search><sort><creationdate>20111001</creationdate><title>Effects of osteoporosis and nutrition supplements on structures and nanomechanical properties of bone tissue</title><author>Chang, Yuan-Ting ; Chen, Chuan-Mu ; Tu, Min-Yu ; Chen, Hsiao-Ling ; Chang, Shou-Yi ; Tsai, Tung-Chou ; Wang, Ying-Ting ; Hsiao, Hsiang-Long</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-571f0178cdc6f624e5a13482d091294d183122ef22155ffaa7b7c699f67034923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Biomechanical Phenomena</topic><topic>Biomedical materials</topic><topic>Bone</topic><topic>Bone and Bones - diagnostic imaging</topic><topic>Bone and Bones - metabolism</topic><topic>Bone and Bones - pathology</topic><topic>Bone and Bones - physiopathology</topic><topic>Bone Density</topic><topic>Bones</topic><topic>Collagen - chemistry</topic><topic>Collagen - metabolism</topic><topic>Density</topic><topic>Dietary Supplements</topic><topic>Durapatite - chemistry</topic><topic>Durapatite - metabolism</topic><topic>Female</topic><topic>Fracture mechanics</topic><topic>Fractures, Bone - complications</topic><topic>Mechanical Phenomena</topic><topic>Mechanical property</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Nanoindentation</topic><topic>Nanostructure</topic><topic>Nanotechnology</topic><topic>Nutrition</topic><topic>Osteoporosis</topic><topic>Osteoporosis - complications</topic><topic>Osteoporosis - metabolism</topic><topic>Osteoporosis - pathology</topic><topic>Osteoporosis - physiopathology</topic><topic>Scanning electron microscopy</topic><topic>Surgical implants</topic><topic>X-Ray Microtomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chang, Yuan-Ting</creatorcontrib><creatorcontrib>Chen, Chuan-Mu</creatorcontrib><creatorcontrib>Tu, Min-Yu</creatorcontrib><creatorcontrib>Chen, Hsiao-Ling</creatorcontrib><creatorcontrib>Chang, Shou-Yi</creatorcontrib><creatorcontrib>Tsai, Tung-Chou</creatorcontrib><creatorcontrib>Wang, Ying-Ting</creatorcontrib><creatorcontrib>Hsiao, Hsiang-Long</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><jtitle>Journal of the mechanical behavior of biomedical materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chang, Yuan-Ting</au><au>Chen, Chuan-Mu</au><au>Tu, Min-Yu</au><au>Chen, Hsiao-Ling</au><au>Chang, Shou-Yi</au><au>Tsai, Tung-Chou</au><au>Wang, Ying-Ting</au><au>Hsiao, Hsiang-Long</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of osteoporosis and nutrition supplements on structures and nanomechanical properties of bone tissue</atitle><jtitle>Journal of the mechanical behavior of biomedical materials</jtitle><addtitle>J Mech Behav Biomed Mater</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>4</volume><issue>7</issue><spage>1412</spage><epage>1420</epage><pages>1412-1420</pages><issn>1751-6161</issn><eissn>1878-0180</eissn><abstract>In this study, the bone structures, nanomechanical properties and fracture behaviors in different groups of female C57BL/6 mice (control, sham operated, ovariectomized, casein supplemented, and fermented milk supplemented) were examined by micro-computed tomography, scanning and transmission electron microscopy, and nanoindentation. The control and sham operated mice showed dense bone structures with high cortical bone mineral densities of 544 mg/cm
3 (average) and high hardness of 0.9–1.1 GPa; resistance to bone fracture was conferred by microcracking, crack deflections and ligament bridging attributed to aligned collagen fibers and densely packed hydroxyapatite crystals. Bone mineral density, hardness and fracture resistance in ovariectomized mice markedly dropped due to loose bone structure with randomly distributed collagens and hydroxyapatites. The acidic casein supplemented mice with blood acidosis exhibited poor mineral absorption and loose bone structure, whereas the neutralized casein or fermented milk supplemented mice were resistant to osteoporosis and had high bone mechanical properties.
[Display omitted]</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>21783151</pmid><doi>10.1016/j.jmbbm.2011.05.011</doi><tpages>9</tpages></addata></record> |
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| subjects | Animals Biomechanical Phenomena Biomedical materials Bone Bone and Bones - diagnostic imaging Bone and Bones - metabolism Bone and Bones - pathology Bone and Bones - physiopathology Bone Density Bones Collagen - chemistry Collagen - metabolism Density Dietary Supplements Durapatite - chemistry Durapatite - metabolism Female Fracture mechanics Fractures, Bone - complications Mechanical Phenomena Mechanical property Mice Mice, Inbred C57BL Nanoindentation Nanostructure Nanotechnology Nutrition Osteoporosis Osteoporosis - complications Osteoporosis - metabolism Osteoporosis - pathology Osteoporosis - physiopathology Scanning electron microscopy Surgical implants X-Ray Microtomography |
| title | Effects of osteoporosis and nutrition supplements on structures and nanomechanical properties of bone tissue |
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