Copper-Catalyzed Borylation Reactions of Alkynes and Arynes

Copper-Catalyzed Borylation Reactions of Alkynes and Arynes

One, two, three, four: A copper(I)–phosphine complex catalyzes the diborylation of alkynes and arynes, and the tri‐ or tetraborylation of propargyl ethers (see scheme; pin=pinacolato). In the latter cases, the CO bond(s) as well as the CC bond are borylated in one pot. Furthermore, a diborylation...

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Veröffentlicht in:Angewandte Chemie International Edition 2012-01, Vol.51 (1), p.235-238
Hauptverfasser: Yoshida, Hiroto, Kawashima, Shota, Takemoto, Yuki, Okada, Kengo, Ohshita, Joji, Takaki, Ken
Format: Artikel
Sprache:eng
Schlagworte:
alkynes
arynes
boron
copper
total synthesis
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Zusammenfassung:One, two, three, four: A copper(I)–phosphine complex catalyzes the diborylation of alkynes and arynes, and the tri‐ or tetraborylation of propargyl ethers (see scheme; pin=pinacolato). In the latter cases, the CO bond(s) as well as the CC bond are borylated in one pot. Furthermore, a diborylation product serves as an intermediate in the efficient synthesis of ortho‐terphenyls with pharmacological activity.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201106706