Nocodazole is a High-Affinity Ligand for the Cancer-Related Kinases ABL, c-KIT, BRAF, and MEK
New from old: Nocodazole displays high affinity for a set of cancer‐related kinases, including ABL, c‐KIT, BRAF, and MEK. These experimental and computational findings may provide insight into the design of new and potent inhibitors of common kinases based on the nocodazole scaffold.
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| Veröffentlicht in: | ChemMedChem 2012-01, Vol.7 (1), p.53-56 |
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| creator | Park, Hwangseo Hong, Seunghee Hong, Sungwoo |
| description | New from old: Nocodazole displays high affinity for a set of cancer‐related kinases, including ABL, c‐KIT, BRAF, and MEK. These experimental and computational findings may provide insight into the design of new and potent inhibitors of common kinases based on the nocodazole scaffold. |
| doi_str_mv | 10.1002/cmdc.201100410 |
| format | Article |
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| ispartof | ChemMedChem, 2012-01, Vol.7 (1), p.53-56 |
| issn | 1860-7179 1860-7187 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | ABL anticancer agents Antineoplastic Agents - pharmacology Humans inhibitors kinases Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinase Kinases - metabolism Models, Molecular Neoplasms - drug therapy Neoplasms - enzymology nocodazole Nocodazole - pharmacology Proto-Oncogene Proteins B-raf - antagonists & inhibitors Proto-Oncogene Proteins B-raf - metabolism Proto-Oncogene Proteins c-abl - antagonists & inhibitors Proto-Oncogene Proteins c-abl - metabolism Proto-Oncogene Proteins c-kit - antagonists & inhibitors Proto-Oncogene Proteins c-kit - metabolism |
| title | Nocodazole is a High-Affinity Ligand for the Cancer-Related Kinases ABL, c-KIT, BRAF, and MEK |
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