Nocodazole is a High-Affinity Ligand for the Cancer-Related Kinases ABL, c-KIT, BRAF, and MEK

New from old: Nocodazole displays high affinity for a set of cancer‐related kinases, including ABL, c‐KIT, BRAF, and MEK. These experimental and computational findings may provide insight into the design of new and potent inhibitors of common kinases based on the nocodazole scaffold.

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Bibliographische Detailangaben
Veröffentlicht in:	ChemMedChem 2012-01, Vol.7 (1), p.53-56
Hauptverfasser:	Park, Hwangseo, Hong, Seunghee, Hong, Sungwoo
Format:	Artikel
Sprache:	eng
Schlagworte:	ABL anticancer agents Antineoplastic Agents - pharmacology Humans inhibitors kinases Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinase Kinases - metabolism Models, Molecular Neoplasms - drug therapy Neoplasms - enzymology nocodazole Nocodazole - pharmacology Proto-Oncogene Proteins B-raf - antagonists & inhibitors Proto-Oncogene Proteins B-raf - metabolism Proto-Oncogene Proteins c-abl - antagonists & inhibitors Proto-Oncogene Proteins c-abl - metabolism Proto-Oncogene Proteins c-kit - antagonists & inhibitors Proto-Oncogene Proteins c-kit - metabolism
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Beschreibung
Zusammenfassung:	New from old: Nocodazole displays high affinity for a set of cancer‐related kinases, including ABL, c‐KIT, BRAF, and MEK. These experimental and computational findings may provide insight into the design of new and potent inhibitors of common kinases based on the nocodazole scaffold.
ISSN:	1860-7179 1860-7187
DOI:	10.1002/cmdc.201100410