Design of Multifunctional Micelle for Tumor-Targeted Intracellular Drug Release and Fluorescent Imaging

A novel multifunctional polymeric micelle bearing a pH‐tunable on‐off module for programmed drug release, folate for tumor targeting, and quantum dots for fluorescent imaging is described. The micelle can turn drug release off at neutral pH whereas on inside lysosomes. QD functionalization allows a...

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Veröffentlicht in:	Advanced materials (Weinheim) 2012-01, Vol.24 (1), p.115-120
Hauptverfasser:	Wang, Weiwei, Cheng, Du, Gong, Faming, Miao, Xiangmin, Shuai, Xintao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - administration & dosage cancer treatment Drug Carriers - chemistry drug delivery Fluoresceins - chemistry Fluorescence Resonance Energy Transfer fluorescent imaging Hydrogen-Ion Concentration Mice Mice, Nude Micelles Microscopy, Confocal Neoplasms - drug therapy Paclitaxel - administration & dosage pH-sensitive on-off Quantum Dots
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Beschreibung
Zusammenfassung:	A novel multifunctional polymeric micelle bearing a pH‐tunable on‐off module for programmed drug release, folate for tumor targeting, and quantum dots for fluorescent imaging is described. The micelle can turn drug release off at neutral pH whereas on inside lysosomes. QD functionalization allows a clear elucidation of pH‐tunable drug release and facile visualization of in vivo delivery event.
ISSN:	0935-9648 1521-4095
DOI:	10.1002/adma.201104066